Human ES-derived MSCs correct TNF-α-mediated alterations in a blood–brain barrier model

Human ES-derived MSCs correct TNF-α-mediated alterations in a blood–brain barrier model

Abstract Background Immune cell trafficking into the CNS is considered to contribute to pathogenesis in MS and its animal model, EAE. Disruption of the blood–brain barrier (BBB) is a hallmark of these pathologies and a potential target of therapeutics. Human embryonic stem cell-derived mesenchymal s...

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Bibliographic Details
Main Authors: Shujun Ge, Xi Jiang, Debayon Paul, Li Song, Xiaofang Wang, Joel S. Pachter
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Fluids and Barriers of the CNS
Subjects:
Blood brain barrier
Brain endothelial cells
Mesenchymal stem/stromal cells
Tight junction
MS and EAE
Online Access:http://link.springer.com/article/10.1186/s12987-019-0138-5

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