Targeting insulin-like growth factor axis in hepatocellular carcinoma

<p>Abstract</p> <p>The insulin-like growth factor (IGF) axis contains ligands, receptors, substrates, and ligand binding proteins. The essential role of IGF axis in hepatocellular carcinoma (HCC) has been illustrated in HCC cell lines and in animal xenograft models. Preclinical evi...

Full description

Bibliographic Details
Main Authors: Wu Jennifer, Zhu Andrew X
Format: Article
Language:English
Published: BMC 2011-07-01
Series:Journal of Hematology & Oncology
Online Access:http://www.jhoonline.org/content/4/1/30
id doaj-94d8c563be6b4ad5b7b5dba2b0593443
record_format Article
spelling doaj-94d8c563be6b4ad5b7b5dba2b05934432020-11-24T22:17:23ZengBMCJournal of Hematology & Oncology1756-87222011-07-01413010.1186/1756-8722-4-30Targeting insulin-like growth factor axis in hepatocellular carcinomaWu JenniferZhu Andrew X<p>Abstract</p> <p>The insulin-like growth factor (IGF) axis contains ligands, receptors, substrates, and ligand binding proteins. The essential role of IGF axis in hepatocellular carcinoma (HCC) has been illustrated in HCC cell lines and in animal xenograft models. Preclinical evidence provides ample indication that all four components of IGF axis are crucial in the carcinogenic and metastatic potential of HCC. Several strategies targeting this system including monoclonal antibodies against the IGF 1 receptor (IGF-1R) and small molecule inhibitors of the tyrosine kinase function of IGF-1R are under active investigation. This review describes the most up-to-date understanding of this complex axis in HCC, and provides relevant information on clinical trials targeting the IGF axis in HCC with a focus on anti-IGF-1R approach. IGF axis is increasingly recognized as one of the most relevant pathways in HCC and agents targeting this axis can potentially play an important role in the treatment of HCC.</p> http://www.jhoonline.org/content/4/1/30
collection DOAJ
language English
format Article
sources DOAJ
author Wu Jennifer
Zhu Andrew X
spellingShingle Wu Jennifer
Zhu Andrew X
Targeting insulin-like growth factor axis in hepatocellular carcinoma
Journal of Hematology & Oncology
author_facet Wu Jennifer
Zhu Andrew X
author_sort Wu Jennifer
title Targeting insulin-like growth factor axis in hepatocellular carcinoma
title_short Targeting insulin-like growth factor axis in hepatocellular carcinoma
title_full Targeting insulin-like growth factor axis in hepatocellular carcinoma
title_fullStr Targeting insulin-like growth factor axis in hepatocellular carcinoma
title_full_unstemmed Targeting insulin-like growth factor axis in hepatocellular carcinoma
title_sort targeting insulin-like growth factor axis in hepatocellular carcinoma
publisher BMC
series Journal of Hematology & Oncology
issn 1756-8722
publishDate 2011-07-01
description <p>Abstract</p> <p>The insulin-like growth factor (IGF) axis contains ligands, receptors, substrates, and ligand binding proteins. The essential role of IGF axis in hepatocellular carcinoma (HCC) has been illustrated in HCC cell lines and in animal xenograft models. Preclinical evidence provides ample indication that all four components of IGF axis are crucial in the carcinogenic and metastatic potential of HCC. Several strategies targeting this system including monoclonal antibodies against the IGF 1 receptor (IGF-1R) and small molecule inhibitors of the tyrosine kinase function of IGF-1R are under active investigation. This review describes the most up-to-date understanding of this complex axis in HCC, and provides relevant information on clinical trials targeting the IGF axis in HCC with a focus on anti-IGF-1R approach. IGF axis is increasingly recognized as one of the most relevant pathways in HCC and agents targeting this axis can potentially play an important role in the treatment of HCC.</p>
url http://www.jhoonline.org/content/4/1/30
work_keys_str_mv AT wujennifer targetinginsulinlikegrowthfactoraxisinhepatocellularcarcinoma
AT zhuandrewx targetinginsulinlikegrowthfactoraxisinhepatocellularcarcinoma
_version_ 1725784881409032192