Nicotine Changes the microRNA Profile to Regulate the FOXO Memory Program of CD8+ T Cells in Rheumatoid Arthritis

Nicotine Changes the microRNA Profile to Regulate the FOXO Memory Program of CD8+ T Cells in Rheumatoid Arthritis

Objective: Smoking suppresses PD-1 expression in patients with rheumatoid arthritis (RA). In this study, we assess if smoking changed the epigenetic control over CD8+ T cell memory formation through a microRNA (miR) dependent mechanism.Methods: Phenotypes of CD8+ T cells from smokers and non-smokers...

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Bibliographic Details
Main Authors: Caroline Wasén, Caroline Ospelt, Alessandro Camponeschi, Malin C. Erlandsson, Karin M. E. Andersson, Sofia Töyrä Silfverswärd, Steffen Gay, Maria I. Bokarewa
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
microRNA
FOXO signaling pathway
programmed cell death 1 (PD-1)
memory T cell
CD8+ T cell
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01474/full

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