APC conditional knock-out mouse is a model of infantile spasms with elevated neuronal β-catenin levels, neonatal spasms, and chronic seizures

APC conditional knock-out mouse is a model of infantile spasms with elevated neuronal β-catenin levels, neonatal spasms, and chronic seizures

Infantile spasms (IS) are a catastrophic childhood epilepsy syndrome characterized by flexion-extension spasms during infancy that progress to chronic seizures and cognitive deficits in later life. The molecular causes of IS are poorly defined. Genetic screens of individuals with IS have identified...

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Bibliographic Details
Main Authors: Antonella Pirone, Jonathan Alexander, Lauren A. Lau, David Hampton, Andrew Zayachkivsky, Amy Yee, Audrey Yee, Michele H. Jacob, Chris G. Dulla
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Neurobiology of Disease
Subjects:
Infantile spasms
Epilepsy
β-Catenin
Wnt signaling
Cortex
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116302534

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