Response to sunitinib in combination with proton beam radiation in a patient with chondrosarcoma: a case report

• Main Authors: Dallas Jennifer, Imanirad Iman, Rajani Rajiv, Dagan Roi, Subbiah Sukanthini, Gaa Rebecca, Dwarica Wayne A, Ivey Alison M, Zlotecki Robert A, Malyapa Robert, Indelicato Danny J, Scarborough Mark T, Reith John D, Gibbs C Parker, Dang Long H
• Format: Article
• Language: English
• Published: BMC 2012-01-01
• Series: Journal of Medical Case Reports
• Online Access: http://www.jmedicalcasereports.com/content/6/1/41

<p>Abstract</p> <p>Introduction</p> <p>Chondrosarcoma is well-known to be primarily resistant to conventional radiation and chemotherapy.</p> <p>Case presentation</p> <p>We present the case of a 32-year-old Caucasian man with clear cell chondrosarcoma who presented with symptomatic recurrence in his pelvis and metastases to his skull and lungs. Our patient underwent systemic therapy with sunitinib and then consolidation with proton beam radiation to his symptomatic site. He achieved complete symptomatic relief with a significantly improved performance status and had an almost complete and durable metabolic response on fluorine-18-fluorodeoxyglucose positron emission tomography.</p> <p>Conclusions</p> <p>Our findings have important clinical implications and suggest novel clinical trials for this difficult to treat disease.</p>