Toxicity and Metal Corrosion of Glutaraldehyde-Didecyldimethylammonium Bromide as a Disinfectant Agent

The wide use of disinfectants has prompted resistance from the microbiome which will in turn reduce the bactericidal effect of disinfectants. Hence, glutaraldehyde (GA) and didecyldimethylammonium bromide (DDAB) were used to develop a combination disinfectant with high stability and antimicrobial ef...

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Main Authors:	Wenshu Lin, Bing Niu, Jialin Yi, Zhirui Deng, Jiang Song, Qin Chen
Format:	Article
Language:	English
Published:	Hindawi Limited 2018-01-01
Series:	BioMed Research International
Online Access:	http://dx.doi.org/10.1155/2018/9814209

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spelling	doaj-94cbf16442284a89a540b3bbd7a328092020-11-24T21:09:08ZengHindawi LimitedBioMed Research International2314-61332314-61412018-01-01201810.1155/2018/98142099814209Toxicity and Metal Corrosion of Glutaraldehyde-Didecyldimethylammonium Bromide as a Disinfectant AgentWenshu Lin0Bing Niu1Jialin Yi2Zhirui Deng3Jiang Song4Qin Chen5Shanghai Key Laboratory of Bio-Energy Crops, School of Life Sciences, Shanghai University, Shanghai, ChinaShanghai Key Laboratory of Bio-Energy Crops, School of Life Sciences, Shanghai University, Shanghai, ChinaShanghai Key Laboratory of Bio-Energy Crops, School of Life Sciences, Shanghai University, Shanghai, ChinaShanghai Key Laboratory of Bio-Energy Crops, School of Life Sciences, Shanghai University, Shanghai, ChinaShanghai Key Laboratory of Bio-Energy Crops, School of Life Sciences, Shanghai University, Shanghai, ChinaShanghai Key Laboratory of Bio-Energy Crops, School of Life Sciences, Shanghai University, Shanghai, ChinaThe wide use of disinfectants has prompted resistance from the microbiome which will in turn reduce the bactericidal effect of disinfectants. Hence, glutaraldehyde (GA) and didecyldimethylammonium bromide (DDAB) were used to develop a combination disinfectant with high stability and antimicrobial effects, which was named GA-DDAB combination disinfectant (GD). The bactericidal mechanism against Escherichia coli was studied in our earlier work. In this study, we focused on GD’s bactericidal efficacy in both the laboratory and environment, the genetic toxicity to mouse lymphoma L5178Y TK+/− cells, acute peroral toxicity in mice, and its metal corrosion properties with a view to providing theoretical support for developing a high-efficiency, low toxicity, and weakly corrosive disinfectant for general use.http://dx.doi.org/10.1155/2018/9814209
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Wenshu Lin Bing Niu Jialin Yi Zhirui Deng Jiang Song Qin Chen
spellingShingle	Wenshu Lin Bing Niu Jialin Yi Zhirui Deng Jiang Song Qin Chen Toxicity and Metal Corrosion of Glutaraldehyde-Didecyldimethylammonium Bromide as a Disinfectant Agent BioMed Research International
author_facet	Wenshu Lin Bing Niu Jialin Yi Zhirui Deng Jiang Song Qin Chen
author_sort	Wenshu Lin
title	Toxicity and Metal Corrosion of Glutaraldehyde-Didecyldimethylammonium Bromide as a Disinfectant Agent
title_short	Toxicity and Metal Corrosion of Glutaraldehyde-Didecyldimethylammonium Bromide as a Disinfectant Agent
title_full	Toxicity and Metal Corrosion of Glutaraldehyde-Didecyldimethylammonium Bromide as a Disinfectant Agent
title_fullStr	Toxicity and Metal Corrosion of Glutaraldehyde-Didecyldimethylammonium Bromide as a Disinfectant Agent
title_full_unstemmed	Toxicity and Metal Corrosion of Glutaraldehyde-Didecyldimethylammonium Bromide as a Disinfectant Agent
title_sort	toxicity and metal corrosion of glutaraldehyde-didecyldimethylammonium bromide as a disinfectant agent
publisher	Hindawi Limited
series	BioMed Research International
issn	2314-6133 2314-6141
publishDate	2018-01-01
description	The wide use of disinfectants has prompted resistance from the microbiome which will in turn reduce the bactericidal effect of disinfectants. Hence, glutaraldehyde (GA) and didecyldimethylammonium bromide (DDAB) were used to develop a combination disinfectant with high stability and antimicrobial effects, which was named GA-DDAB combination disinfectant (GD). The bactericidal mechanism against Escherichia coli was studied in our earlier work. In this study, we focused on GD’s bactericidal efficacy in both the laboratory and environment, the genetic toxicity to mouse lymphoma L5178Y TK+/− cells, acute peroral toxicity in mice, and its metal corrosion properties with a view to providing theoretical support for developing a high-efficiency, low toxicity, and weakly corrosive disinfectant for general use.
url	http://dx.doi.org/10.1155/2018/9814209
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Toxicity and Metal Corrosion of Glutaraldehyde-Didecyldimethylammonium Bromide as a Disinfectant Agent

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