Dimerization deficiency of enigmatic retinitis pigmentosa-linked rhodopsin mutants

Retinitis pigmentosa is often caused by mutations that affect the activity or transport of rhodopsin, but some mutations cause disease even though an apparently functional protein is produced. Here the authors show that three such enigmatic mutants retain scramblase activity but are unable to dimeri...

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Main Authors:	Birgit Ploier, Lydia N. Caro, Takefumi Morizumi, Kalpana Pandey, Jillian N. Pearring, Michael A. Goren, Silvia C. Finnemann, Johannes Graumann, Vadim Y. Arshavsky, Jeremy S. Dittman, Oliver P. Ernst, Anant K. Menon
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms12832

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spelling	doaj-94c82e6657484b44baee46822dc7c91b2021-05-11T10:34:51ZengNature Publishing GroupNature Communications2041-17232016-10-017111110.1038/ncomms12832Dimerization deficiency of enigmatic retinitis pigmentosa-linked rhodopsin mutantsBirgit Ploier0Lydia N. Caro1Takefumi Morizumi2Kalpana Pandey3Jillian N. Pearring4Michael A. Goren5Silvia C. Finnemann6Johannes Graumann7Vadim Y. Arshavsky8Jeremy S. Dittman9Oliver P. Ernst10Anant K. Menon11Department of Biochemistry, Weill Cornell Medical CollegeDepartment of Biochemistry, University of TorontoDepartment of Biochemistry, University of TorontoDepartment of Biochemistry, Weill Cornell Medical CollegeDepartment of Ophthalmology, Duke University Medical CenterDepartment of Biochemistry, Weill Cornell Medical CollegeDepartment of Biological Sciences, Center for Cancer, Genetic Diseases and Gene Regulation, Fordham UniversityDepartment of Biochemistry, Weill Cornell Medical CollegeDepartment of Ophthalmology, Duke University Medical CenterDepartment of Biochemistry, Weill Cornell Medical CollegeDepartment of Biochemistry, University of TorontoDepartment of Biochemistry, Weill Cornell Medical CollegeRetinitis pigmentosa is often caused by mutations that affect the activity or transport of rhodopsin, but some mutations cause disease even though an apparently functional protein is produced. Here the authors show that three such enigmatic mutants retain scramblase activity but are unable to dimerize.https://doi.org/10.1038/ncomms12832
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Birgit Ploier Lydia N. Caro Takefumi Morizumi Kalpana Pandey Jillian N. Pearring Michael A. Goren Silvia C. Finnemann Johannes Graumann Vadim Y. Arshavsky Jeremy S. Dittman Oliver P. Ernst Anant K. Menon
spellingShingle	Birgit Ploier Lydia N. Caro Takefumi Morizumi Kalpana Pandey Jillian N. Pearring Michael A. Goren Silvia C. Finnemann Johannes Graumann Vadim Y. Arshavsky Jeremy S. Dittman Oliver P. Ernst Anant K. Menon Dimerization deficiency of enigmatic retinitis pigmentosa-linked rhodopsin mutants Nature Communications
author_facet	Birgit Ploier Lydia N. Caro Takefumi Morizumi Kalpana Pandey Jillian N. Pearring Michael A. Goren Silvia C. Finnemann Johannes Graumann Vadim Y. Arshavsky Jeremy S. Dittman Oliver P. Ernst Anant K. Menon
author_sort	Birgit Ploier
title	Dimerization deficiency of enigmatic retinitis pigmentosa-linked rhodopsin mutants
title_short	Dimerization deficiency of enigmatic retinitis pigmentosa-linked rhodopsin mutants
title_full	Dimerization deficiency of enigmatic retinitis pigmentosa-linked rhodopsin mutants
title_fullStr	Dimerization deficiency of enigmatic retinitis pigmentosa-linked rhodopsin mutants
title_full_unstemmed	Dimerization deficiency of enigmatic retinitis pigmentosa-linked rhodopsin mutants
title_sort	dimerization deficiency of enigmatic retinitis pigmentosa-linked rhodopsin mutants
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-10-01
description	Retinitis pigmentosa is often caused by mutations that affect the activity or transport of rhodopsin, but some mutations cause disease even though an apparently functional protein is produced. Here the authors show that three such enigmatic mutants retain scramblase activity but are unable to dimerize.
url	https://doi.org/10.1038/ncomms12832
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Dimerization deficiency of enigmatic retinitis pigmentosa-linked rhodopsin mutants

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