Brønsted acidic ionic liquid catalyzed an efficient and eco-friendly protocol for the synthesis of 2,4,5-trisubstituted-1H-imidazoles under solvent-free conditions

• Main Authors: Janardhan Banothu, Rajitha Gali, Ravibabu Velpula, Rajitha Bavantula
• Format: Article
• Language: English
• Published: Elsevier 2017-05-01
• Series: Arabian Journal of Chemistry
• Subjects: Eco-friendly; Imidazole; Ionic liquid; Solvent-free; Three component reaction
• Online Access: http://www.sciencedirect.com/science/article/pii/S1878535213003626

A simple, highly efficient and eco-friendly protocol for the synthesis of 2,4,5-trisubstituted-1H-imidazoles via one-pot three component condensation of benzil/benzoin, aldehydes and ammonium acetate under solvent-free conditions has been achieved utilizing Brønsted acidic ionic liquid, (4-sulfobutyl)tris(4-sulfophenyl) phosphonium hydrogen sulfate as catalyst. The remarkable features of this methodology are excellent yields in shorter reaction times, cleaner reaction profile, and environmentally benign nature, use of non-toxic, readily synthesizable, inexpensive and recyclable catalyst.