An Alkaline Based Method for Generating Crystalline, Strong, and Shape Memory Polyvinyl Alcohol Biomaterials

Abstract Strong, stretchable, and durable biomaterials with shape memory properties can be useful in different biomedical devices, tissue engineering, and soft robotics. However, it is challenging to combine these features. Semi‐crystalline polyvinyl alcohol (PVA) has been used to make hydrogels by...

Full description

Bibliographic Details
Main Authors: Mohammad Ali Darabi, Ali Khosrozadeh, Ying Wang, Nureddin Ashammakhi, Halima Alem, Ahmet Erdem, Qiang Chang, Kaige Xu, Yuqing Liu, Gaoxing Luo, Ali Khademhosseini, Malcolm Xing
Format: Article
Language:English
Published: Wiley 2020-11-01
Series:Advanced Science
Subjects:
Online Access:https://doi.org/10.1002/advs.201902740
id doaj-94c4311da8b7426e84e8a69bb4f4d7a3
record_format Article
spelling doaj-94c4311da8b7426e84e8a69bb4f4d7a32020-11-25T03:03:52ZengWileyAdvanced Science2198-38442020-11-01721n/an/a10.1002/advs.201902740An Alkaline Based Method for Generating Crystalline, Strong, and Shape Memory Polyvinyl Alcohol BiomaterialsMohammad Ali Darabi0Ali Khosrozadeh1Ying Wang2Nureddin Ashammakhi3Halima Alem4Ahmet Erdem5Qiang Chang6Kaige Xu7Yuqing Liu8Gaoxing Luo9Ali Khademhosseini10Malcolm Xing11Center for Minimally Invasive Therapeutics (C‐MIT) University of California Los Angeles CA 90095 USADepartment of Mechanical Engineering University of Manitoba Winnipeg R3T 5V6 CanadaInstitute of Burn Research State Key Lab of Trauma Burns and Combined Injury Southwest Hospital Third Military Medical University Chongqing 400038 ChinaCenter for Minimally Invasive Therapeutics (C‐MIT) University of California Los Angeles CA 90095 USACenter for Minimally Invasive Therapeutics (C‐MIT) University of California Los Angeles CA 90095 USACenter for Minimally Invasive Therapeutics (C‐MIT) University of California Los Angeles CA 90095 USADepartment of Mechanical Engineering University of Manitoba Winnipeg R3T 5V6 CanadaDepartment of Mechanical Engineering University of Manitoba Winnipeg R3T 5V6 CanadaDepartment of Mechanical Engineering University of Manitoba Winnipeg R3T 5V6 CanadaInstitute of Burn Research State Key Lab of Trauma Burns and Combined Injury Southwest Hospital Third Military Medical University Chongqing 400038 ChinaCenter for Minimally Invasive Therapeutics (C‐MIT) University of California Los Angeles CA 90095 USADepartment of Mechanical Engineering University of Manitoba Winnipeg R3T 5V6 CanadaAbstract Strong, stretchable, and durable biomaterials with shape memory properties can be useful in different biomedical devices, tissue engineering, and soft robotics. However, it is challenging to combine these features. Semi‐crystalline polyvinyl alcohol (PVA) has been used to make hydrogels by conventional methods such as freeze–thaw and chemical crosslinking, but it is formidable to produce strong materials with adjustable properties. Herein, a method to induce crystallinity and produce physically crosslinked PVA hydrogels via applying high‐concentration sodium hydroxide into dense PVA polymer is introduced. Such a strategy enables the production of physically crosslinked PVA biomaterial with high mechanical properties, low water content, resistance to injury, and shape memory properties. It is also found that the developed PVA hydrogel can recover 90% of plastic deformation due to extension upon supplying water, providing a strong contraction force sufficiently to lift objects 1100 times more than their weight. Cytocompatibility, antifouling property, hemocompatibility, and biocompatibility are also demonstrated in vitro and in vivo. The fabrication methods of PVA‐based catheters, injectable electronics, and microfluidic devices are demonstrated. This gelation approach enables both layer‐by‐layer and 3D printing fabrications.https://doi.org/10.1002/advs.201902740biomaterialscathetershydrogelsinjectable electronicsmicrofluidicspolyvinyl alcohol
collection DOAJ
language English
format Article
sources DOAJ
author Mohammad Ali Darabi
Ali Khosrozadeh
Ying Wang
Nureddin Ashammakhi
Halima Alem
Ahmet Erdem
Qiang Chang
Kaige Xu
Yuqing Liu
Gaoxing Luo
Ali Khademhosseini
Malcolm Xing
spellingShingle Mohammad Ali Darabi
Ali Khosrozadeh
Ying Wang
Nureddin Ashammakhi
Halima Alem
Ahmet Erdem
Qiang Chang
Kaige Xu
Yuqing Liu
Gaoxing Luo
Ali Khademhosseini
Malcolm Xing
An Alkaline Based Method for Generating Crystalline, Strong, and Shape Memory Polyvinyl Alcohol Biomaterials
Advanced Science
biomaterials
catheters
hydrogels
injectable electronics
microfluidics
polyvinyl alcohol
author_facet Mohammad Ali Darabi
Ali Khosrozadeh
Ying Wang
Nureddin Ashammakhi
Halima Alem
Ahmet Erdem
Qiang Chang
Kaige Xu
Yuqing Liu
Gaoxing Luo
Ali Khademhosseini
Malcolm Xing
author_sort Mohammad Ali Darabi
title An Alkaline Based Method for Generating Crystalline, Strong, and Shape Memory Polyvinyl Alcohol Biomaterials
title_short An Alkaline Based Method for Generating Crystalline, Strong, and Shape Memory Polyvinyl Alcohol Biomaterials
title_full An Alkaline Based Method for Generating Crystalline, Strong, and Shape Memory Polyvinyl Alcohol Biomaterials
title_fullStr An Alkaline Based Method for Generating Crystalline, Strong, and Shape Memory Polyvinyl Alcohol Biomaterials
title_full_unstemmed An Alkaline Based Method for Generating Crystalline, Strong, and Shape Memory Polyvinyl Alcohol Biomaterials
title_sort alkaline based method for generating crystalline, strong, and shape memory polyvinyl alcohol biomaterials
publisher Wiley
series Advanced Science
issn 2198-3844
publishDate 2020-11-01
description Abstract Strong, stretchable, and durable biomaterials with shape memory properties can be useful in different biomedical devices, tissue engineering, and soft robotics. However, it is challenging to combine these features. Semi‐crystalline polyvinyl alcohol (PVA) has been used to make hydrogels by conventional methods such as freeze–thaw and chemical crosslinking, but it is formidable to produce strong materials with adjustable properties. Herein, a method to induce crystallinity and produce physically crosslinked PVA hydrogels via applying high‐concentration sodium hydroxide into dense PVA polymer is introduced. Such a strategy enables the production of physically crosslinked PVA biomaterial with high mechanical properties, low water content, resistance to injury, and shape memory properties. It is also found that the developed PVA hydrogel can recover 90% of plastic deformation due to extension upon supplying water, providing a strong contraction force sufficiently to lift objects 1100 times more than their weight. Cytocompatibility, antifouling property, hemocompatibility, and biocompatibility are also demonstrated in vitro and in vivo. The fabrication methods of PVA‐based catheters, injectable electronics, and microfluidic devices are demonstrated. This gelation approach enables both layer‐by‐layer and 3D printing fabrications.
topic biomaterials
catheters
hydrogels
injectable electronics
microfluidics
polyvinyl alcohol
url https://doi.org/10.1002/advs.201902740
work_keys_str_mv AT mohammadalidarabi analkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials
AT alikhosrozadeh analkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials
AT yingwang analkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials
AT nureddinashammakhi analkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials
AT halimaalem analkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials
AT ahmeterdem analkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials
AT qiangchang analkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials
AT kaigexu analkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials
AT yuqingliu analkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials
AT gaoxingluo analkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials
AT alikhademhosseini analkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials
AT malcolmxing analkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials
AT mohammadalidarabi alkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials
AT alikhosrozadeh alkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials
AT yingwang alkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials
AT nureddinashammakhi alkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials
AT halimaalem alkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials
AT ahmeterdem alkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials
AT qiangchang alkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials
AT kaigexu alkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials
AT yuqingliu alkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials
AT gaoxingluo alkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials
AT alikhademhosseini alkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials
AT malcolmxing alkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials
_version_ 1724684146535563264