An Alkaline Based Method for Generating Crystalline, Strong, and Shape Memory Polyvinyl Alcohol Biomaterials
Abstract Strong, stretchable, and durable biomaterials with shape memory properties can be useful in different biomedical devices, tissue engineering, and soft robotics. However, it is challenging to combine these features. Semi‐crystalline polyvinyl alcohol (PVA) has been used to make hydrogels by...
Main Authors: | , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wiley
2020-11-01
|
Series: | Advanced Science |
Subjects: | |
Online Access: | https://doi.org/10.1002/advs.201902740 |
id |
doaj-94c4311da8b7426e84e8a69bb4f4d7a3 |
---|---|
record_format |
Article |
spelling |
doaj-94c4311da8b7426e84e8a69bb4f4d7a32020-11-25T03:03:52ZengWileyAdvanced Science2198-38442020-11-01721n/an/a10.1002/advs.201902740An Alkaline Based Method for Generating Crystalline, Strong, and Shape Memory Polyvinyl Alcohol BiomaterialsMohammad Ali Darabi0Ali Khosrozadeh1Ying Wang2Nureddin Ashammakhi3Halima Alem4Ahmet Erdem5Qiang Chang6Kaige Xu7Yuqing Liu8Gaoxing Luo9Ali Khademhosseini10Malcolm Xing11Center for Minimally Invasive Therapeutics (C‐MIT) University of California Los Angeles CA 90095 USADepartment of Mechanical Engineering University of Manitoba Winnipeg R3T 5V6 CanadaInstitute of Burn Research State Key Lab of Trauma Burns and Combined Injury Southwest Hospital Third Military Medical University Chongqing 400038 ChinaCenter for Minimally Invasive Therapeutics (C‐MIT) University of California Los Angeles CA 90095 USACenter for Minimally Invasive Therapeutics (C‐MIT) University of California Los Angeles CA 90095 USACenter for Minimally Invasive Therapeutics (C‐MIT) University of California Los Angeles CA 90095 USADepartment of Mechanical Engineering University of Manitoba Winnipeg R3T 5V6 CanadaDepartment of Mechanical Engineering University of Manitoba Winnipeg R3T 5V6 CanadaDepartment of Mechanical Engineering University of Manitoba Winnipeg R3T 5V6 CanadaInstitute of Burn Research State Key Lab of Trauma Burns and Combined Injury Southwest Hospital Third Military Medical University Chongqing 400038 ChinaCenter for Minimally Invasive Therapeutics (C‐MIT) University of California Los Angeles CA 90095 USADepartment of Mechanical Engineering University of Manitoba Winnipeg R3T 5V6 CanadaAbstract Strong, stretchable, and durable biomaterials with shape memory properties can be useful in different biomedical devices, tissue engineering, and soft robotics. However, it is challenging to combine these features. Semi‐crystalline polyvinyl alcohol (PVA) has been used to make hydrogels by conventional methods such as freeze–thaw and chemical crosslinking, but it is formidable to produce strong materials with adjustable properties. Herein, a method to induce crystallinity and produce physically crosslinked PVA hydrogels via applying high‐concentration sodium hydroxide into dense PVA polymer is introduced. Such a strategy enables the production of physically crosslinked PVA biomaterial with high mechanical properties, low water content, resistance to injury, and shape memory properties. It is also found that the developed PVA hydrogel can recover 90% of plastic deformation due to extension upon supplying water, providing a strong contraction force sufficiently to lift objects 1100 times more than their weight. Cytocompatibility, antifouling property, hemocompatibility, and biocompatibility are also demonstrated in vitro and in vivo. The fabrication methods of PVA‐based catheters, injectable electronics, and microfluidic devices are demonstrated. This gelation approach enables both layer‐by‐layer and 3D printing fabrications.https://doi.org/10.1002/advs.201902740biomaterialscathetershydrogelsinjectable electronicsmicrofluidicspolyvinyl alcohol |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mohammad Ali Darabi Ali Khosrozadeh Ying Wang Nureddin Ashammakhi Halima Alem Ahmet Erdem Qiang Chang Kaige Xu Yuqing Liu Gaoxing Luo Ali Khademhosseini Malcolm Xing |
spellingShingle |
Mohammad Ali Darabi Ali Khosrozadeh Ying Wang Nureddin Ashammakhi Halima Alem Ahmet Erdem Qiang Chang Kaige Xu Yuqing Liu Gaoxing Luo Ali Khademhosseini Malcolm Xing An Alkaline Based Method for Generating Crystalline, Strong, and Shape Memory Polyvinyl Alcohol Biomaterials Advanced Science biomaterials catheters hydrogels injectable electronics microfluidics polyvinyl alcohol |
author_facet |
Mohammad Ali Darabi Ali Khosrozadeh Ying Wang Nureddin Ashammakhi Halima Alem Ahmet Erdem Qiang Chang Kaige Xu Yuqing Liu Gaoxing Luo Ali Khademhosseini Malcolm Xing |
author_sort |
Mohammad Ali Darabi |
title |
An Alkaline Based Method for Generating Crystalline, Strong, and Shape Memory Polyvinyl Alcohol Biomaterials |
title_short |
An Alkaline Based Method for Generating Crystalline, Strong, and Shape Memory Polyvinyl Alcohol Biomaterials |
title_full |
An Alkaline Based Method for Generating Crystalline, Strong, and Shape Memory Polyvinyl Alcohol Biomaterials |
title_fullStr |
An Alkaline Based Method for Generating Crystalline, Strong, and Shape Memory Polyvinyl Alcohol Biomaterials |
title_full_unstemmed |
An Alkaline Based Method for Generating Crystalline, Strong, and Shape Memory Polyvinyl Alcohol Biomaterials |
title_sort |
alkaline based method for generating crystalline, strong, and shape memory polyvinyl alcohol biomaterials |
publisher |
Wiley |
series |
Advanced Science |
issn |
2198-3844 |
publishDate |
2020-11-01 |
description |
Abstract Strong, stretchable, and durable biomaterials with shape memory properties can be useful in different biomedical devices, tissue engineering, and soft robotics. However, it is challenging to combine these features. Semi‐crystalline polyvinyl alcohol (PVA) has been used to make hydrogels by conventional methods such as freeze–thaw and chemical crosslinking, but it is formidable to produce strong materials with adjustable properties. Herein, a method to induce crystallinity and produce physically crosslinked PVA hydrogels via applying high‐concentration sodium hydroxide into dense PVA polymer is introduced. Such a strategy enables the production of physically crosslinked PVA biomaterial with high mechanical properties, low water content, resistance to injury, and shape memory properties. It is also found that the developed PVA hydrogel can recover 90% of plastic deformation due to extension upon supplying water, providing a strong contraction force sufficiently to lift objects 1100 times more than their weight. Cytocompatibility, antifouling property, hemocompatibility, and biocompatibility are also demonstrated in vitro and in vivo. The fabrication methods of PVA‐based catheters, injectable electronics, and microfluidic devices are demonstrated. This gelation approach enables both layer‐by‐layer and 3D printing fabrications. |
topic |
biomaterials catheters hydrogels injectable electronics microfluidics polyvinyl alcohol |
url |
https://doi.org/10.1002/advs.201902740 |
work_keys_str_mv |
AT mohammadalidarabi analkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials AT alikhosrozadeh analkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials AT yingwang analkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials AT nureddinashammakhi analkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials AT halimaalem analkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials AT ahmeterdem analkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials AT qiangchang analkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials AT kaigexu analkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials AT yuqingliu analkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials AT gaoxingluo analkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials AT alikhademhosseini analkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials AT malcolmxing analkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials AT mohammadalidarabi alkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials AT alikhosrozadeh alkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials AT yingwang alkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials AT nureddinashammakhi alkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials AT halimaalem alkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials AT ahmeterdem alkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials AT qiangchang alkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials AT kaigexu alkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials AT yuqingliu alkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials AT gaoxingluo alkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials AT alikhademhosseini alkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials AT malcolmxing alkalinebasedmethodforgeneratingcrystallinestrongandshapememorypolyvinylalcoholbiomaterials |
_version_ |
1724684146535563264 |