Epoxyeicosatrienoic acid (EET)-stimulated angiogenesis is mediated by epoxy hydroxyeicosatrienoic acids (EHETs) formed from COX-2

Epoxyeicosatrienoic acid (EET)-stimulated angiogenesis is mediated by epoxy hydroxyeicosatrienoic acids (EHETs) formed from COX-2

Epoxyeicosatrienoic acids (EETs) are formed from the metabolism of arachidonic acid by cytochrome P450s. EETs promote angiogenesis linked to tumor growth in various cancer models that is attenuated in vivo by cyclooxygenase 2 (COX-2) inhibitors. This study further defines a role for COX-2 in mediati...

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Bibliographic Details
Main Authors: Amy A. Rand, Anita Rajamani, Sean D. Kodani, Todd R. Harris, Lukas Schlatt, Bodgan Barnych, Anthony G. Passerini, Bruce D. Hammock
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Journal of Lipid Research
Subjects:
arachidonic acid
endothelial cells
cyclooxygenase 2
mass spectrometry
cancer
metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520310397

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http://www.sciencedirect.com/science/article/pii/S0022227520310397

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