The new era of treatment for obesity: evidence and expectations for gut microbiome transplantation
Obesity has reached epidemic proportions. Despite a better understanding of the underlying pathophysiology and growing treatment options, a significant proportion of obese patients do not respond to treatment. Recently, microbes residing in the human gastrointestinal tract have been found to act as...
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Frontiers Media S.A.
2016-02-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fcimb.2016.00015/full |
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doaj-94bd2ad81b894ec89e226d5732c3a4fa2020-11-24T22:11:21ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882016-02-01610.3389/fcimb.2016.00015173546The new era of treatment for obesity: evidence and expectations for gut microbiome transplantationThilini N Jayasinghe0Valentina eChiavaroli1David J Holland2Wayne S Cutfield3Wayne S Cutfield4Justin M O'Sullivan5Justin M O'Sullivan6The University of AucklandThe University of AucklandCounties Manukau HealthThe University of AucklandGravida: National centre for growth and developmentThe University of AucklandGravida: National centre for growth and developmentObesity has reached epidemic proportions. Despite a better understanding of the underlying pathophysiology and growing treatment options, a significant proportion of obese patients do not respond to treatment. Recently, microbes residing in the human gastrointestinal tract have been found to act as an endocrine organ, whose composition and functionality may contribute to the development of obesity. Therefore, faecal/gut microbiome transplantation (GMT), which involves the transfer of faeces from a healthy donor to a recipient, is increasingly drawing attention as a potential treatment for obesity. Currently the evidence for GMT effectiveness in the treatment of obesity is preliminary. Here, we summarize benefits, procedures, and issues associated with GMT, with a special focus on obesity.http://journal.frontiersin.org/Journal/10.3389/fcimb.2016.00015/fullObesitymicrobiotamicrobiomeFMTfecal transplantationGIT |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Thilini N Jayasinghe Valentina eChiavaroli David J Holland Wayne S Cutfield Wayne S Cutfield Justin M O'Sullivan Justin M O'Sullivan |
| spellingShingle |
Thilini N Jayasinghe Valentina eChiavaroli David J Holland Wayne S Cutfield Wayne S Cutfield Justin M O'Sullivan Justin M O'Sullivan The new era of treatment for obesity: evidence and expectations for gut microbiome transplantation Frontiers in Cellular and Infection Microbiology Obesity microbiota microbiome FMT fecal transplantation GIT |
| author_facet |
Thilini N Jayasinghe Valentina eChiavaroli David J Holland Wayne S Cutfield Wayne S Cutfield Justin M O'Sullivan Justin M O'Sullivan |
| author_sort |
Thilini N Jayasinghe |
| title |
The new era of treatment for obesity: evidence and expectations for gut microbiome transplantation |
| title_short |
The new era of treatment for obesity: evidence and expectations for gut microbiome transplantation |
| title_full |
The new era of treatment for obesity: evidence and expectations for gut microbiome transplantation |
| title_fullStr |
The new era of treatment for obesity: evidence and expectations for gut microbiome transplantation |
| title_full_unstemmed |
The new era of treatment for obesity: evidence and expectations for gut microbiome transplantation |
| title_sort |
new era of treatment for obesity: evidence and expectations for gut microbiome transplantation |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Cellular and Infection Microbiology |
| issn |
2235-2988 |
| publishDate |
2016-02-01 |
| description |
Obesity has reached epidemic proportions. Despite a better understanding of the underlying pathophysiology and growing treatment options, a significant proportion of obese patients do not respond to treatment. Recently, microbes residing in the human gastrointestinal tract have been found to act as an endocrine organ, whose composition and functionality may contribute to the development of obesity. Therefore, faecal/gut microbiome transplantation (GMT), which involves the transfer of faeces from a healthy donor to a recipient, is increasingly drawing attention as a potential treatment for obesity. Currently the evidence for GMT effectiveness in the treatment of obesity is preliminary. Here, we summarize benefits, procedures, and issues associated with GMT, with a special focus on obesity. |
| topic |
Obesity microbiota microbiome FMT fecal transplantation GIT |
| url |
http://journal.frontiersin.org/Journal/10.3389/fcimb.2016.00015/full |
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