LOW AND HIGH RESPONDERS AFTER POLYPROPYLENE MESH IMPLANTATION FOR INGUINAL HERNIOPLASTY

• Main Author: Justyba Godos
• Format: Article
• Language: English
• Published: Associazione Italiana Giovani Medici 2017-10-01
• Series: Euromediterranean Biomedical Journal
• Subjects: IL-6; hernioplasty; inflammatory response; polypropylene mesh.
• Online Access: http://www.embj.org/joomla335/index.php?option=com_k2&view=item&id=310:inguinal-hernioplasty-implantation-mesh&Itemid=17

The aim of the study was to evaluate individual inflammatory response after inguinal hernioplasty by measuring baseline and post-operative serum IL-6 response to surgery and quantifying the variability of the serum response in a homogeneous group of patients.Patients enrolled in the study underwent inguinal hernioplasty. Blood samples were used to analyze serum IL-6, TNF-alpha, LOOH and GSH levels. To identify high and low IL-6 responders, patients were divided into 2 groups according median values of the peak levels of IL-6. Mean levels of the cytokine were comparable at baseline but reached peak at 6 h and persisted elevated at following hours among high responders whereas remained significantly lower over time among low responders.Patients identified as low responders showed not significant changes in serum IL-6 levels over the post-operative period. In contrast, high responders demonstrated a significant response reaching the peak level of IL-6 after 6 hours post operation.