LOW AND HIGH RESPONDERS AFTER POLYPROPYLENE MESH IMPLANTATION FOR INGUINAL HERNIOPLASTY
The aim of the study was to evaluate individual inflammatory response after inguinal hernioplasty by measuring baseline and post-operative serum IL-6 response to surgery and quantifying the variability of the serum response in a homogeneous group of patients.Patients enrolled in the study underwent...
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| Format: | Article |
| Language: | English |
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Associazione Italiana Giovani Medici
2017-10-01
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| Series: | Euromediterranean Biomedical Journal |
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| Online Access: | http://www.embj.org/joomla335/index.php?option=com_k2&view=item&id=310:inguinal-hernioplasty-implantation-mesh&Itemid=17 |
| Summary: | The aim of the study was to evaluate individual inflammatory response after inguinal hernioplasty by measuring baseline and post-operative serum IL-6 response to surgery and quantifying the variability of the serum response in a homogeneous group of patients.Patients enrolled in the study underwent inguinal hernioplasty. Blood samples were used to analyze serum IL-6, TNF-alpha, LOOH and GSH levels. To identify high and low IL-6 responders, patients were divided into 2 groups according median values of the peak levels of IL-6. Mean levels of the cytokine were comparable at baseline but reached peak at 6 h and persisted elevated at following hours among high responders whereas remained significantly lower over time among low responders.Patients identified as low responders showed not significant changes in serum IL-6 levels over the post-operative period. In contrast, high responders demonstrated a significant response reaching the peak level of IL-6 after 6 hours post operation. |
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| ISSN: | 2279-7165 2279-7165 |