A landscape of genomic alterations at the root of a near-untreatable tuberculosis epidemic

A landscape of genomic alterations at the root of a near-untreatable tuberculosis epidemic

Abstract Background Atypical Beijing genotype Mycobacterium tuberculosis strains are widespread in South Africa and have acquired resistance to up to 13 drugs on multiple occasions. It is puzzling that these strains have retained fitness and transmissibility despite the potential fitness cost associ...

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Bibliographic Details
Main Authors: Marisa Klopper, Tim Hermanus Heupink, Grant Hill-Cawthorne, Elizabeth Maria Streicher, Anzaan Dippenaar, Margaretha de Vos, Abdallah Musa Abdallah, Jason Limberis, Matthias Merker, Scott Burns, Stefan Niemann, Keertan Dheda, James Posey, Arnab Pain, Robin Mark Warren
Format: Article
Language:English
Published: BMC 2020-02-01
Series:BMC Medicine
Subjects:
Tuberculosis
Drug-resistant
Beyond-XDR-TB
Missed resistance
Weakened regimen
Whole genome sequencing
Online Access:http://link.springer.com/article/10.1186/s12916-019-1487-2

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http://link.springer.com/article/10.1186/s12916-019-1487-2

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