Traumatic Brain Injury Accelerates the Onset of Cognitive Dysfunction and Aggravates Alzheimer's-Like Pathology in the Hippocampus by Altering the Phenotype of Microglia in the APP/PS1 Mouse Model

Traumatic Brain Injury Accelerates the Onset of Cognitive Dysfunction and Aggravates Alzheimer's-Like Pathology in the Hippocampus by Altering the Phenotype of Microglia in the APP/PS1 Mouse Model

An increasing number of studies have suggested that traumatic brain injury (TBI) is associated with some neurodegenerative diseases, including Alzheimer's disease (AD). Various aspects of the mechanism of TBI-induced AD have been elucidated. However, there are also studies opposing the view tha...

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Bibliographic Details
Main Authors: Di Wu, Jay Prakash P. Kumal, Xiaodi Lu, Yixuan Li, Dongsheng Mao, Xudong Tang, Meitong Nie, Xin Liu, Liang Sun, Bin Liu, Yafang Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Neurology
Subjects:
traumatic brain injury
Alzheimer's disease
Aβ plaque pathology
neuroinflammation
microglia
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2021.666430/full

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