Strain specific resistance to murine scrapie associated with a naturally occurring human prion protein polymorphism at residue 171.

Strain specific resistance to murine scrapie associated with a naturally occurring human prion protein polymorphism at residue 171.

Transmissible spongiform encephalopathies (TSE) or prion diseases are neurodegenerative disorders associated with conversion of normal host prion protein (PrP) to a misfolded, protease-resistant form (PrPres). Genetic variations of prion protein in humans and animals can alter susceptibility to both...

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Bibliographic Details
Main Authors: James F Striebel, Brent Race, Kimberly D Meade-White, Rachel LaCasse, Bruce Chesebro
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-09-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3182929?pdf=render

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