Acute and Chronic Effects of Protein Kinase-D Signaling on Cardiac Energy Metabolism

Acute and Chronic Effects of Protein Kinase-D Signaling on Cardiac Energy Metabolism

Protein kinase-D (PKD) is increasingly recognized as a key regulatory signaling hub in cardiac glucose uptake and also a major player in the development of hypertrophy. Glucose is one of the predominant energy substrates for the heart to support contraction. However, a cardiac substrate switch towar...

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Bibliographic Details
Main Authors: Ozlenen Simsek Papur, Aomin Sun, Jan F. C. Glatz, Joost J. F. P. Luiken, Miranda Nabben
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
protein kinase D
PKD isoforms
glucose uptake
fatty acid uptake
cardiac hypertrophy
membrane substrate transporter
Online Access:https://www.frontiersin.org/article/10.3389/fcvm.2018.00065/full

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