Very low-protein diet to postpone renal failure: Pathophysiology and clinical applications in chronic kidney disease

The uremic syndrome is a metabolic disorder characterized by the impairment of renal handling of several solutes, the resulting accumulation of toxic products and the activation of some adaptive but detrimental mechanisms which all together contribute to the progression of renal damage. In moderate...

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Main Authors:	Vincenzo Bellizzi, Patrizia Calella, Juan Jesus Carrero, Denis Fouque
Format:	Article
Language:	English
Published:	KeAi Communications Co., Ltd. 2018-03-01
Series:	Chronic Diseases and Translational Medicine
Online Access:	http://www.sciencedirect.com/science/article/pii/S2095882X18300021

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spelling	doaj-94a9e55ccf004c76b878a6cba2e555322021-03-02T09:14:13ZengKeAi Communications Co., Ltd.Chronic Diseases and Translational Medicine2095-882X2018-03-01414550Very low-protein diet to postpone renal failure: Pathophysiology and clinical applications in chronic kidney diseaseVincenzo Bellizzi0Patrizia Calella1Juan Jesus Carrero2Denis Fouque3Nephrology Unit, University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, Salerno 84131, Italy; European Renal Nutrition – ERN, Working Group at the European Renal Association - European Dialysis Transplant Association – ERA-EDTA; Corresponding author. Division of Nephrology, Dialysis & Transplantation, University Hospital “San Giovanni di Dio e Ruggi d'Aragona”, Via San Leonardo, Salerno 84131, Italy.Department of Movement and Wellness Sciences, University of Naples Parthenope, Naples 80133, ItalyEuropean Renal Nutrition – ERN, Working Group at the European Renal Association - European Dialysis Transplant Association – ERA-EDTA; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, SwedenEuropean Renal Nutrition – ERN, Working Group at the European Renal Association - European Dialysis Transplant Association – ERA-EDTA; Renal Unit, Université de Lyon, Centre Hospitalier Lyon-SUD, Lyon 69495, FranceThe uremic syndrome is a metabolic disorder characterized by the impairment of renal handling of several solutes, the resulting accumulation of toxic products and the activation of some adaptive but detrimental mechanisms which all together contribute to the progression of renal damage. In moderate to advanced renal failure, the dietary manipulation of nutrients improves metabolic abnormalities and may contribute to delay the time of dialysis initiation. This commentary focuses on the physiopathological rationale and the clinical application of the very low-protein diet supplemented with ketoanalogs for the management of chronic kidney disease. Keywords: Low-protein diet, Ketoanalogs, Renal failure, Chronic kidney diseasehttp://www.sciencedirect.com/science/article/pii/S2095882X18300021
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Vincenzo Bellizzi Patrizia Calella Juan Jesus Carrero Denis Fouque
spellingShingle	Vincenzo Bellizzi Patrizia Calella Juan Jesus Carrero Denis Fouque Very low-protein diet to postpone renal failure: Pathophysiology and clinical applications in chronic kidney disease Chronic Diseases and Translational Medicine
author_facet	Vincenzo Bellizzi Patrizia Calella Juan Jesus Carrero Denis Fouque
author_sort	Vincenzo Bellizzi
title	Very low-protein diet to postpone renal failure: Pathophysiology and clinical applications in chronic kidney disease
title_short	Very low-protein diet to postpone renal failure: Pathophysiology and clinical applications in chronic kidney disease
title_full	Very low-protein diet to postpone renal failure: Pathophysiology and clinical applications in chronic kidney disease
title_fullStr	Very low-protein diet to postpone renal failure: Pathophysiology and clinical applications in chronic kidney disease
title_full_unstemmed	Very low-protein diet to postpone renal failure: Pathophysiology and clinical applications in chronic kidney disease
title_sort	very low-protein diet to postpone renal failure: pathophysiology and clinical applications in chronic kidney disease
publisher	KeAi Communications Co., Ltd.
series	Chronic Diseases and Translational Medicine
issn	2095-882X
publishDate	2018-03-01
description	The uremic syndrome is a metabolic disorder characterized by the impairment of renal handling of several solutes, the resulting accumulation of toxic products and the activation of some adaptive but detrimental mechanisms which all together contribute to the progression of renal damage. In moderate to advanced renal failure, the dietary manipulation of nutrients improves metabolic abnormalities and may contribute to delay the time of dialysis initiation. This commentary focuses on the physiopathological rationale and the clinical application of the very low-protein diet supplemented with ketoanalogs for the management of chronic kidney disease. Keywords: Low-protein diet, Ketoanalogs, Renal failure, Chronic kidney disease
url	http://www.sciencedirect.com/science/article/pii/S2095882X18300021
work_keys_str_mv	AT vincenzobellizzi verylowproteindiettopostponerenalfailurepathophysiologyandclinicalapplicationsinchronickidneydisease AT patriziacalella verylowproteindiettopostponerenalfailurepathophysiologyandclinicalapplicationsinchronickidneydisease AT juanjesuscarrero verylowproteindiettopostponerenalfailurepathophysiologyandclinicalapplicationsinchronickidneydisease AT denisfouque verylowproteindiettopostponerenalfailurepathophysiologyandclinicalapplicationsinchronickidneydisease
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Very low-protein diet to postpone renal failure: Pathophysiology and clinical applications in chronic kidney disease

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