THE EFFECT OF VITAMIN E SUPPLEMENTATION ON LIPID PROFILE AND OXIDATIVE STRESS MARKERS IN HEMODIALYSIS PATIENTS
<p class="abstract"><strong>Abstract</strong></p> <p class="abstract"><strong>INTRODUCTION: </strong>Dyslipidemia and oxidative stress are thought to be important mechanisms in pathogenesis of disease in hemodialysis patients. This study...
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| Format: | Article |
| Language: | English |
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Vesnu Publications
2010-12-01
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| Series: | ARYA Atherosclerosis |
| Online Access: | http://arya.mui.ac.ir/index.php/arya/article/view/114 |
| Summary: | <p class="abstract"><strong>Abstract</strong></p> <p class="abstract"><strong>INTRODUCTION: </strong>Dyslipidemia and oxidative stress are thought to be important mechanisms in pathogenesis of disease in hemodialysis patients. This study was designed to investigate the efficacy of oral vitamin E supplementation on lipid profile and oxidative stress in hemodialysis patients.</p> <p class="abstract"><strong>METHODS: </strong>The study group consisted of 26 uremic patients (10 women and 16 men), 16-68 years of age undergoing maintenance hemodialysis three times a week (12 hours/week), lasting a range of 6-108 months, at Vali-e-Asre Hospital in Birjand (Iran). Total Antioxidant Capacity (TAC), lipid peroxidation, cholesterol, triglyceride, high-density lipoprotein and low-density lipoprotein levels were determined before and after oral vitamin E supplementation, 400 mg/d for 90 days.</p> <p class="abstract"><strong>RESULTS:</strong> Vitamin E supplementation caused a significant decrease in ThioBarbituric Acid Reactive Substances (TBARS) level as a marker for lipid peroxidation (2.97±0.52 vs. 2.55±0.44, P<0.001) and a significant increase in plasma TAC (1252±348 vs. 1398±372, P<0.01). Although there was a decrease in the level of lipid profile, there were no statistically significant differences in the means of cholesterol, triglyceride, high-density lipoprotein and low-density lipoprotein before and after vitamin E supplementation among patients.</p> <p class="abstract"><strong>CONCLUSION:</strong> Our results indicated that oral vitamin E supplementation might be able to modify oxidative stress by an increase in TAC, and a decrease in lipid peroxidation; that could be considered as a preventive strategy in hemodialysis patients</p> <p class="abstract"> </p><table cellspacing="0" cellpadding="0" align="left"><tbody><tr><td width="35" height="12"> </td></tr> <tr><td> </td> <td> </td></tr></tbody></table><p class="abstract"> </p> <br /> <p class="abstract"><strong>Keywords:</strong> Antioxidant capacity, lipid peroxidation, lipid profile, vitamin E, hemodialysis.</p> <p class="abstract"> </p> |
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| ISSN: | 1735-3955 2251-6638 |