Comparative In Vivo Effects of Hemoglobin-Based Oxygen Carriers (HBOC) with Varying Prooxidant and Physiological Reactivity.

Comparative In Vivo Effects of Hemoglobin-Based Oxygen Carriers (HBOC) with Varying Prooxidant and Physiological Reactivity.

A series of hemoglobin-based oxygen carrier candidates (HBOC), previously noted for their differences in prooxidative and physiological reactivity, were compared in terms of the negative effects displayed upon injection in Wistar rats. At the concentrations tested, antioxidant strategies based on al...

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Main Authors: Vlad Al Toma, Anca D Farcaș, Ioana Roman, Bogdan Sevastre, Denisa Hathazi, Florina Scurtu, Grigore Damian, Radu Silaghi-Dumitrescu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4838227?pdf=render
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spelling doaj-949e2e975de3488a970dd47dec556d0f2020-11-24T21:40:56ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01114e015390910.1371/journal.pone.0153909Comparative In Vivo Effects of Hemoglobin-Based Oxygen Carriers (HBOC) with Varying Prooxidant and Physiological Reactivity.Vlad Al TomaAnca D FarcașIoana RomanBogdan SevastreDenisa HathaziFlorina ScurtuGrigore DamianRadu Silaghi-DumitrescuA series of hemoglobin-based oxygen carrier candidates (HBOC), previously noted for their differences in prooxidative and physiological reactivity, were compared in terms of the negative effects displayed upon injection in Wistar rats. At the concentrations tested, antioxidant strategies based on albumin as well as based on rubrerythrin appear to offer observable physiological advantages.http://europepmc.org/articles/PMC4838227?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Vlad Al Toma
Anca D Farcaș
Ioana Roman
Bogdan Sevastre
Denisa Hathazi
Florina Scurtu
Grigore Damian
Radu Silaghi-Dumitrescu
spellingShingle Vlad Al Toma
Anca D Farcaș
Ioana Roman
Bogdan Sevastre
Denisa Hathazi
Florina Scurtu
Grigore Damian
Radu Silaghi-Dumitrescu
Comparative In Vivo Effects of Hemoglobin-Based Oxygen Carriers (HBOC) with Varying Prooxidant and Physiological Reactivity.
PLoS ONE
author_facet Vlad Al Toma
Anca D Farcaș
Ioana Roman
Bogdan Sevastre
Denisa Hathazi
Florina Scurtu
Grigore Damian
Radu Silaghi-Dumitrescu
author_sort Vlad Al Toma
title Comparative In Vivo Effects of Hemoglobin-Based Oxygen Carriers (HBOC) with Varying Prooxidant and Physiological Reactivity.
title_short Comparative In Vivo Effects of Hemoglobin-Based Oxygen Carriers (HBOC) with Varying Prooxidant and Physiological Reactivity.
title_full Comparative In Vivo Effects of Hemoglobin-Based Oxygen Carriers (HBOC) with Varying Prooxidant and Physiological Reactivity.
title_fullStr Comparative In Vivo Effects of Hemoglobin-Based Oxygen Carriers (HBOC) with Varying Prooxidant and Physiological Reactivity.
title_full_unstemmed Comparative In Vivo Effects of Hemoglobin-Based Oxygen Carriers (HBOC) with Varying Prooxidant and Physiological Reactivity.
title_sort comparative in vivo effects of hemoglobin-based oxygen carriers (hboc) with varying prooxidant and physiological reactivity.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2016-01-01
description A series of hemoglobin-based oxygen carrier candidates (HBOC), previously noted for their differences in prooxidative and physiological reactivity, were compared in terms of the negative effects displayed upon injection in Wistar rats. At the concentrations tested, antioxidant strategies based on albumin as well as based on rubrerythrin appear to offer observable physiological advantages.
url http://europepmc.org/articles/PMC4838227?pdf=render
work_keys_str_mv AT vladaltoma comparativeinvivoeffectsofhemoglobinbasedoxygencarriershbocwithvaryingprooxidantandphysiologicalreactivity
AT ancadfarcas comparativeinvivoeffectsofhemoglobinbasedoxygencarriershbocwithvaryingprooxidantandphysiologicalreactivity
AT ioanaroman comparativeinvivoeffectsofhemoglobinbasedoxygencarriershbocwithvaryingprooxidantandphysiologicalreactivity
AT bogdansevastre comparativeinvivoeffectsofhemoglobinbasedoxygencarriershbocwithvaryingprooxidantandphysiologicalreactivity
AT denisahathazi comparativeinvivoeffectsofhemoglobinbasedoxygencarriershbocwithvaryingprooxidantandphysiologicalreactivity
AT florinascurtu comparativeinvivoeffectsofhemoglobinbasedoxygencarriershbocwithvaryingprooxidantandphysiologicalreactivity
AT grigoredamian comparativeinvivoeffectsofhemoglobinbasedoxygencarriershbocwithvaryingprooxidantandphysiologicalreactivity
AT radusilaghidumitrescu comparativeinvivoeffectsofhemoglobinbasedoxygencarriershbocwithvaryingprooxidantandphysiologicalreactivity
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