Overview of microRNA-199a Regulation in Cancer

• Main Authors: Wang Q, Ye B, Wang P, Yao F, Zhang C, Yu G
• Format: Article
• Language: English
• Published: Dove Medical Press 2019-12-01
• Series: Cancer Management and Research
• Subjects: microrna-199a; target genes; carcinoma; biomarker; regulatory mechanisms
• Online Access: https://www.dovepress.com/overview-of-microrna-199a-regulation-in-cancer-peer-reviewed-article-CMAR

Qiwen Wang,1,2,* Bingyu Ye,1,2,* Ping Wang,1,2 Fenjie Yao,1,2 Chunyan Zhang,1,2 Guoying Yu1,2 1Henan International Joint Laboratory of Pulmonary Fibrosis, College of Life Science, Henan Normal University, Xinxiang 453007, Henan, People’s Republic of China; 2State Key Laboratory Cell Differentiation and Regulation, College of Life Science, Henan Normal University, Xinxiang 453007, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chunyan Zhang; Guoying YuCollege of Life Science, Henan Normal University, 46# East of Construction Road, Xinxiang, Henan 453007, People’s Republic of ChinaTel [phone]; [phone]Fax [phone]Email [e-mail]; [e-mail]: microRNAs (miRNAs) are a class of endogenous short, non-coding RNAs that regulate a multitude of genes at the post-transcriptional level. miR-199, which is a highly conserved miRNA family, consists of miR-199a and miR-199b. Researchers mainly focused on miR-199a over the past few years. Functional studies have demonstrated that mature miR-199a is a key player in the maintenance of normal homeostasis and in the regulation of disease pathogenesis. Here, we summarize the biological functions of miR-199a and review recent research on its roles in the physiological processes of cancer cells, such as proliferation, migration, invasion, apoptosis, autophagy and glycometabolism.Keywords: microRNA-199a, target genes, carcinoma, biomarker, regulatory mechanisms