Genomic instability at the 13q31 locus and somatic mtDNA mutation in the D-loop site correlate with tumor aggressiveness in sporadic Brazilian breast cancer cases

Genomic instability at the 13q31 locus and somatic mtDNA mutation in the D-loop site correlate with tumor aggressiveness in sporadic Brazilian breast cancer cases

OBJECTIVE: Genomic instability is a hallmark of malignant tissues. In this work, we aimed to characterize nuclear and mitochondrial instabilities by determining short tandem repeats and somatic mitochondrial mutations, respectively, in a cohort of Brazilian sporadic breast cancer cases. Furthermore,...

Full description

Bibliographic Details
Main Authors: Gilson Costa dos Santos-Jr, Andréa Carla de Souza Góoes, Humberto de Vitto, Carla Cristina Moreira, Elizabeth Avvad, Franklin David Rumjanek, Claudia Vitoria de Moura Gallo
Format: Article
Language:English
Published: Faculdade de Medicina / USP 2012-10-01
Series:Clinics
Subjects:
Breast Cancer
STRs
Allelic Imbalance
LOH
Somatic mtDNA Mutation
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322012001000010

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322012001000010

Similar Items