Profound Nanoscale Structural and Biomechanical Changes in DNA Helix upon Treatment with Anthracycline Drugs

Profound Nanoscale Structural and Biomechanical Changes in DNA Helix upon Treatment with Anthracycline Drugs

In our study, we describe the outcomes of the intercalation of different anthracycline antibiotics in double-stranded DNA at the nanoscale and single molecule level. Atomic force microscopy analysis revealed that intercalation results in significant elongation and thinning of dsDNA molecules. Additi...

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Bibliographic Details
Main Authors: Aleksandra Kaczorowska, Weronika Lamperska, Kaja Frączkowska, Jan Masajada, Sławomir Drobczyński, Marta Sobas, Tomasz Wróbel, Kinga Chybicka, Radosław Tarkowski, Sebastian Kraszewski, Halina Podbielska, Wojciech Kałas, Marta Kopaczyńska
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
optical tweezers
DNA stiffness
cell nuclei stiffness
DNA structural changes
Online Access:https://www.mdpi.com/1422-0067/21/11/4142

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