Extracellular HSP70 Activates ERK1/2, NF-kB and Pro-Inflammatory Gene Transcription Through Binding with RAGE in A549 Human Lung Cancer Cells

Extracellular HSP70 Activates ERK1/2, NF-kB and Pro-Inflammatory Gene Transcription Through Binding with RAGE in A549 Human Lung Cancer Cells

Background/Aims: Heat shock protein 70 (HSP70) has been recently described with extracellular actions, where it is actively released in inflammatory conditions. Acting as DAMPs (damage associated molecular pattern), extracellular HSP70 (eHSP70) interacts with membrane receptors and activates inflamm...

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Bibliographic Details
Main Authors: Nauana Somensi, Pedro Ozorio Brum, Vitor de Miranda Ramos, Juciano Gasparotto, Alfeu Zanotto-Filho, Diana Carolina Rostirolla, Maurilio da Silva Morrone, José Claudio Fonseca Moreira, Daniel Pens Gelain
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-08-01
Series:Cellular Physiology and Biochemistry
Subjects:
eHSP70
RAGE
ERK
NF-κB
Inflammation
Lung cancer
Online Access:http://www.karger.com/Article/FullText/480213

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