The Role of P2X7 Purinergic Receptors in the Renal Inflammation Associated with Angiotensin II-induced Hypertension

The Role of P2X7 Purinergic Receptors in the Renal Inflammation Associated with Angiotensin II-induced Hypertension

Purinergic receptors play a central role in the renal pathophysiology of angiotensin II-induced hypertension, since elevated ATP chronically activates P2X7 receptors in this model. The changes induced by the P2X antagonist Brilliant blue G (BBG) in glomerular hemodynamics and in tubulointerstitial i...

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Bibliographic Details
Main Authors: Rocio Bautista-Pérez, Oscar Pérez-Méndez, Agustina Cano-Martínez, Ursino Pacheco, José Santamaría, Fernando Rodríguez-Sámano Bernardo Rodríguez-Iturbe, L. Gabriel Navar, Martha Franco
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
Purinergic receptors
P2X7 receptors
inflammation
kidney
hypertension
Angiotensin II
Online Access:https://www.mdpi.com/1422-0067/21/11/4041

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