MYRF is a membrane-associated transcription factor that autoproteolytically cleaves to directly activate myelin genes.

MYRF is a membrane-associated transcription factor that autoproteolytically cleaves to directly activate myelin genes.

The myelination of axons is a crucial step during vertebrate central nervous system (CNS) development, allowing for rapid and energy efficient saltatory conduction of nerve impulses. Accordingly, the differentiation of oligodendrocytes, the myelinating cells of the CNS, and their expression of myeli...

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Main Authors: Helena Bujalka, Matthias Koenning, Stacey Jackson, Victoria M Perreau, Bernard Pope, Curtis M Hay, Stanlislaw Mitew, Andrew F Hill, Q Richard Lu, Michael Wegner, Rajini Srinivasan, John Svaren, Melanie Willingham, Ben A Barres, Ben Emery
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23966833/?tool=EBI

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