Nanolipoparticles-mediated MDR1 siRNA delivery reduces doxorubicin resistance in breast cancer cells and silences MDR1 expression in xenograft model of human breast cancer

Nanolipoparticles-mediated MDR1 siRNA delivery reduces doxorubicin resistance in breast cancer cells and silences MDR1 expression in xenograft model of human breast cancer

Objective(s): P-glycoprotein (P-gp) is an efflux protein, the overexpression of which has been associated with multidrug resistance in various cancers. Although siRNA delivery to reverse P-gp expression may be promising for sensitizing of tumor cells to cytotoxic drugs, the therapeutic use of siRNA...

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Bibliographic Details
Main Authors: Mahnaz Nourbakhsh, Mahmoud Reza Jaafari, Hermann Lage, Khalil Abnous, Fatemeh mosaffa, Ali Badiee, Javad Behravan
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2015-04-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
Breast cancer
Gene therapy
Liposome
Multidrug resistance
siRNA delivery
Tumor targeting
Online Access:http://ijbms.mums.ac.ir/pdf_4288_fdb3a388d96b0a870f29bc9dc963f267.html

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