In Vitro Expansion of Human Hepatocytes is Restricted by Telomere-Dependent Replicative Aging
Currently, different techniques to expand human hepatocytes in vitro are being investigated to generate enough cells for liver-directed cell therapies. However, based on observations in fibroblasts and other cell types, telomere attrition limits the proliferative capacity of normal somatic cells. Th...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2003-11-01
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| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.3727/000000003771000138 |