Inhibition of inflammation using diacerein markedly improved renal function in endotoxemic acute kidney injured mice

Inhibition of inflammation using diacerein markedly improved renal function in endotoxemic acute kidney injured mice

Abstract Background Inflammation is an important pathogenic component of endotoxemia-induced acute kidney injury (AKI), finally resulting in renal failure. Diacerein is an interleukin-1β (IL-1β) inhibitor used for osteoarthritis treatment by exerting anti-inflammatory effects. This study aims to inv...

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Bibliographic Details
Main Authors: Guangzhe Yu, Qian Liu, Xuening Dong, Kaihong Tang, Bohui Li, Chunmei Liu, Wenzheng Zhang, Yiduo Wang, Yingyu Jin
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Cellular & Molecular Biology Letters
Subjects:
Endotoxemia
Acute kidney injury
Inflammation
Aquaporins
Sodium transporters
Diacerein
Online Access:http://link.springer.com/article/10.1186/s11658-018-0107-z

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