Diagnostic Performance of Simulated Abbreviated MRI for Early-Stage Hepatocellular Carcinoma Screening: A Comparison to Conventional Dynamic Contrast-Enhanced MRI

Purpose To compare the per-patient diagnostic performance of simulated abbreviated MRI (AMRI) to that of conventional MRI (CMRI) with full-sequence dynamic gadoxetic acid (GA) enhancement for early-stage hepatocellular carcinoma (HCC) screening in high-risk patients. Materials and Methods A total...

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Main Authors: Eun Sol Lim, Sung Mo Kim, Sang Soo Shin, Suk Hee Heo, Jong Eun Lee, Yong Yeon Jeong
Format: Article
Language:English
Published: The Korean Society of Radiology 2021-09-01
Series:대한영상의학회지
Subjects:
Online Access:https://doi.org/10.3348/jksr.2020.0172
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spelling doaj-9445b352bcd74042b0bcdc52b82f22222021-09-30T05:09:23ZengThe Korean Society of Radiology대한영상의학회지2288-29282021-09-0182512181230https://doi.org/10.3348/jksr.2020.0172Diagnostic Performance of Simulated Abbreviated MRI for Early-Stage Hepatocellular Carcinoma Screening: A Comparison to Conventional Dynamic Contrast-Enhanced MRIEun Sol LimSung Mo KimSang Soo ShinSuk Hee HeoJong Eun LeeYong Yeon JeongPurpose To compare the per-patient diagnostic performance of simulated abbreviated MRI (AMRI) to that of conventional MRI (CMRI) with full-sequence dynamic gadoxetic acid (GA) enhancement for early-stage hepatocellular carcinoma (HCC) screening in high-risk patients. Materials and Methods A total of 201 consecutive patients at high-risk for HCC, who underwent 3T liver MRI, were included in this retrospective study. The AMRI protocol comprised T2-weighted imaging, hepatobiliary phase imaging after GA injection, and diffusion-weighted imaging. For each patient, two AMRI and CMRI image sets were independently reviewed by two radiologists. Inter-reader agreement was assessed using Cohen’s kappa value. A composite reference standard was used to determine the diagnostic performance of each image set for each reader. Results A total of 93 HCCs were detected in 79 patients. The inter-reader agreement was almost perfect for both image sets (κ = 0.839, 0.948). In AMRI, the per-patient sensitivity and negative predictive values (NPV) were 94.9% and 96.4%, respectively. In CMRI, the per-patient sensitivity and NPV were 96.2% and 97.5%, respectively. Conclusion AMRI, using only three sequences, had a comparable diagnostic performance to CMRI in screening early-stage HCC. AMRI could be an alternative HCC screening tool for highrisk HCC patients.https://doi.org/10.3348/jksr.2020.0172hepatocellular carcinomalivermagnetic resonance imaging
collection DOAJ
language English
format Article
sources DOAJ
author Eun Sol Lim
Sung Mo Kim
Sang Soo Shin
Suk Hee Heo
Jong Eun Lee
Yong Yeon Jeong
spellingShingle Eun Sol Lim
Sung Mo Kim
Sang Soo Shin
Suk Hee Heo
Jong Eun Lee
Yong Yeon Jeong
Diagnostic Performance of Simulated Abbreviated MRI for Early-Stage Hepatocellular Carcinoma Screening: A Comparison to Conventional Dynamic Contrast-Enhanced MRI
대한영상의학회지
hepatocellular carcinoma
liver
magnetic resonance imaging
author_facet Eun Sol Lim
Sung Mo Kim
Sang Soo Shin
Suk Hee Heo
Jong Eun Lee
Yong Yeon Jeong
author_sort Eun Sol Lim
title Diagnostic Performance of Simulated Abbreviated MRI for Early-Stage Hepatocellular Carcinoma Screening: A Comparison to Conventional Dynamic Contrast-Enhanced MRI
title_short Diagnostic Performance of Simulated Abbreviated MRI for Early-Stage Hepatocellular Carcinoma Screening: A Comparison to Conventional Dynamic Contrast-Enhanced MRI
title_full Diagnostic Performance of Simulated Abbreviated MRI for Early-Stage Hepatocellular Carcinoma Screening: A Comparison to Conventional Dynamic Contrast-Enhanced MRI
title_fullStr Diagnostic Performance of Simulated Abbreviated MRI for Early-Stage Hepatocellular Carcinoma Screening: A Comparison to Conventional Dynamic Contrast-Enhanced MRI
title_full_unstemmed Diagnostic Performance of Simulated Abbreviated MRI for Early-Stage Hepatocellular Carcinoma Screening: A Comparison to Conventional Dynamic Contrast-Enhanced MRI
title_sort diagnostic performance of simulated abbreviated mri for early-stage hepatocellular carcinoma screening: a comparison to conventional dynamic contrast-enhanced mri
publisher The Korean Society of Radiology
series 대한영상의학회지
issn 2288-2928
publishDate 2021-09-01
description Purpose To compare the per-patient diagnostic performance of simulated abbreviated MRI (AMRI) to that of conventional MRI (CMRI) with full-sequence dynamic gadoxetic acid (GA) enhancement for early-stage hepatocellular carcinoma (HCC) screening in high-risk patients. Materials and Methods A total of 201 consecutive patients at high-risk for HCC, who underwent 3T liver MRI, were included in this retrospective study. The AMRI protocol comprised T2-weighted imaging, hepatobiliary phase imaging after GA injection, and diffusion-weighted imaging. For each patient, two AMRI and CMRI image sets were independently reviewed by two radiologists. Inter-reader agreement was assessed using Cohen’s kappa value. A composite reference standard was used to determine the diagnostic performance of each image set for each reader. Results A total of 93 HCCs were detected in 79 patients. The inter-reader agreement was almost perfect for both image sets (κ = 0.839, 0.948). In AMRI, the per-patient sensitivity and negative predictive values (NPV) were 94.9% and 96.4%, respectively. In CMRI, the per-patient sensitivity and NPV were 96.2% and 97.5%, respectively. Conclusion AMRI, using only three sequences, had a comparable diagnostic performance to CMRI in screening early-stage HCC. AMRI could be an alternative HCC screening tool for highrisk HCC patients.
topic hepatocellular carcinoma
liver
magnetic resonance imaging
url https://doi.org/10.3348/jksr.2020.0172
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