Diagnostic Performance of Simulated Abbreviated MRI for Early-Stage Hepatocellular Carcinoma Screening: A Comparison to Conventional Dynamic Contrast-Enhanced MRI
Purpose To compare the per-patient diagnostic performance of simulated abbreviated MRI (AMRI) to that of conventional MRI (CMRI) with full-sequence dynamic gadoxetic acid (GA) enhancement for early-stage hepatocellular carcinoma (HCC) screening in high-risk patients. Materials and Methods A total...
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The Korean Society of Radiology
2021-09-01
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doaj-9445b352bcd74042b0bcdc52b82f22222021-09-30T05:09:23ZengThe Korean Society of Radiology대한영상의학회지2288-29282021-09-0182512181230https://doi.org/10.3348/jksr.2020.0172Diagnostic Performance of Simulated Abbreviated MRI for Early-Stage Hepatocellular Carcinoma Screening: A Comparison to Conventional Dynamic Contrast-Enhanced MRIEun Sol LimSung Mo KimSang Soo ShinSuk Hee HeoJong Eun LeeYong Yeon JeongPurpose To compare the per-patient diagnostic performance of simulated abbreviated MRI (AMRI) to that of conventional MRI (CMRI) with full-sequence dynamic gadoxetic acid (GA) enhancement for early-stage hepatocellular carcinoma (HCC) screening in high-risk patients. Materials and Methods A total of 201 consecutive patients at high-risk for HCC, who underwent 3T liver MRI, were included in this retrospective study. The AMRI protocol comprised T2-weighted imaging, hepatobiliary phase imaging after GA injection, and diffusion-weighted imaging. For each patient, two AMRI and CMRI image sets were independently reviewed by two radiologists. Inter-reader agreement was assessed using Cohen’s kappa value. A composite reference standard was used to determine the diagnostic performance of each image set for each reader. Results A total of 93 HCCs were detected in 79 patients. The inter-reader agreement was almost perfect for both image sets (κ = 0.839, 0.948). In AMRI, the per-patient sensitivity and negative predictive values (NPV) were 94.9% and 96.4%, respectively. In CMRI, the per-patient sensitivity and NPV were 96.2% and 97.5%, respectively. Conclusion AMRI, using only three sequences, had a comparable diagnostic performance to CMRI in screening early-stage HCC. AMRI could be an alternative HCC screening tool for highrisk HCC patients.https://doi.org/10.3348/jksr.2020.0172hepatocellular carcinomalivermagnetic resonance imaging |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eun Sol Lim Sung Mo Kim Sang Soo Shin Suk Hee Heo Jong Eun Lee Yong Yeon Jeong |
spellingShingle |
Eun Sol Lim Sung Mo Kim Sang Soo Shin Suk Hee Heo Jong Eun Lee Yong Yeon Jeong Diagnostic Performance of Simulated Abbreviated MRI for Early-Stage Hepatocellular Carcinoma Screening: A Comparison to Conventional Dynamic Contrast-Enhanced MRI 대한영상의학회지 hepatocellular carcinoma liver magnetic resonance imaging |
author_facet |
Eun Sol Lim Sung Mo Kim Sang Soo Shin Suk Hee Heo Jong Eun Lee Yong Yeon Jeong |
author_sort |
Eun Sol Lim |
title |
Diagnostic Performance of Simulated Abbreviated MRI for Early-Stage Hepatocellular Carcinoma Screening: A Comparison to Conventional Dynamic Contrast-Enhanced MRI |
title_short |
Diagnostic Performance of Simulated Abbreviated MRI for Early-Stage Hepatocellular Carcinoma Screening: A Comparison to Conventional Dynamic Contrast-Enhanced MRI |
title_full |
Diagnostic Performance of Simulated Abbreviated MRI for Early-Stage Hepatocellular Carcinoma Screening: A Comparison to Conventional Dynamic Contrast-Enhanced MRI |
title_fullStr |
Diagnostic Performance of Simulated Abbreviated MRI for Early-Stage Hepatocellular Carcinoma Screening: A Comparison to Conventional Dynamic Contrast-Enhanced MRI |
title_full_unstemmed |
Diagnostic Performance of Simulated Abbreviated MRI for Early-Stage Hepatocellular Carcinoma Screening: A Comparison to Conventional Dynamic Contrast-Enhanced MRI |
title_sort |
diagnostic performance of simulated abbreviated mri for early-stage hepatocellular carcinoma screening: a comparison to conventional dynamic contrast-enhanced mri |
publisher |
The Korean Society of Radiology |
series |
대한영상의학회지 |
issn |
2288-2928 |
publishDate |
2021-09-01 |
description |
Purpose To compare the per-patient diagnostic performance of simulated abbreviated MRI
(AMRI) to that of conventional MRI (CMRI) with full-sequence dynamic gadoxetic acid (GA) enhancement
for early-stage hepatocellular carcinoma (HCC) screening in high-risk patients.
Materials and Methods A total of 201 consecutive patients at high-risk for HCC, who underwent
3T liver MRI, were included in this retrospective study. The AMRI protocol comprised T2-weighted
imaging, hepatobiliary phase imaging after GA injection, and diffusion-weighted imaging. For
each patient, two AMRI and CMRI image sets were independently reviewed by two radiologists.
Inter-reader agreement was assessed using Cohen’s kappa value. A composite reference standard
was used to determine the diagnostic performance of each image set for each reader.
Results A total of 93 HCCs were detected in 79 patients. The inter-reader agreement was almost
perfect for both image sets (κ = 0.839, 0.948). In AMRI, the per-patient sensitivity and negative
predictive values (NPV) were 94.9% and 96.4%, respectively. In CMRI, the per-patient sensitivity
and NPV were 96.2% and 97.5%, respectively.
Conclusion AMRI, using only three sequences, had a comparable diagnostic performance to
CMRI in screening early-stage HCC. AMRI could be an alternative HCC screening tool for highrisk
HCC patients. |
topic |
hepatocellular carcinoma liver magnetic resonance imaging |
url |
https://doi.org/10.3348/jksr.2020.0172 |
work_keys_str_mv |
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