Antinuclear Antibodies With a Homogeneous and Speckled Immunofluorescence Pattern Are Associated With Lack of Cancer While Those With a Nucleolar Pattern With the Presence of Cancer

Background: Different antinuclear antibody (ANA) patterns have been associated with the presence of cancer, while other are typically seen in autoimmune diseases. This study aims to investigate the association between ANA and cancer, focusing on patients with ANA with a nucleolar indirect immunofluo...

Full description

Bibliographic Details
Main Authors: Amandine Gauderon, Pascale Roux-Lombard, David Spoerl
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Medicine
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fmed.2020.00165/full
id doaj-9439f8f28d0b4f4ea251a3f33309b180
record_format Article
spelling doaj-9439f8f28d0b4f4ea251a3f33309b1802020-11-25T03:11:23ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2020-04-01710.3389/fmed.2020.00165511713Antinuclear Antibodies With a Homogeneous and Speckled Immunofluorescence Pattern Are Associated With Lack of Cancer While Those With a Nucleolar Pattern With the Presence of CancerAmandine Gauderon0Pascale Roux-Lombard1Pascale Roux-Lombard2David Spoerl3David Spoerl4Division of Immunology and Allergy, Department of Medical Specialties, University Hospital and Faculty of Medicine, Geneva, SwitzerlandDivision of Immunology and Allergy, Department of Medical Specialties, University Hospital and Faculty of Medicine, Geneva, SwitzerlandDivision of Laboratory Medicine, Department of Diagnostic, Geneva University Hospitals, Geneva, SwitzerlandDivision of Immunology and Allergy, Department of Medical Specialties, University Hospital and Faculty of Medicine, Geneva, SwitzerlandDivision of Laboratory Medicine, Department of Diagnostic, Geneva University Hospitals, Geneva, SwitzerlandBackground: Different antinuclear antibody (ANA) patterns have been associated with the presence of cancer, while other are typically seen in autoimmune diseases. This study aims to investigate the association between ANA and cancer, focusing on patients with ANA with a nucleolar indirect immunofluorescence (IIF) pattern.Materials and Methods: ANA patterns and positivity of antibodies against nuclear antigens (NA), in particular those responsible for a nucleolar ANA pattern and/or associated with systemic sclerosis (CENP-A/B, fibrillarin, Ku, NOR-90, PM/Scl-100, PM/Scl-75, RNAP-III, Scl-70, Ro52/TRIM21, and Th/To) were analyzed and correlated to an internal database of patients with cancer.Results: The study included 15,728 patients who had an ANA analysis, 386 patients who had immunodot analysis for antibody/ies against/to specific NA and 15,701 patients diagnosed with cancer. The presence of ANA with a nucleolar pattern showed an increased relative risk (RR 1.5, 95%CI 1.03-2.3) for an associated cancer. Anti-Scl70 and anti-RNAP-III were associated with cancer in 15 and 14%, respectively. The presence of ANA with a homogeneous & speckled (HS) pattern was significantly associated with the absence of cancer (p < 0.01). Patients with a HS pattern were found to have a lower relative risk (RR 0.7, 95%CI 0.5-0.9) of having cancer compared to those with other patterns.Conclusions: Larger studies are needed to investigate which particular antibody/ies against/to specific NA is responsible for the association between nucleolar ANA and cancer, but anti-Scl70 and anti-RNAP-III, which is frequently associated with the presence of anti-RNAP-I, are good candidates to explain this association. Patients with a nucleolar pattern might be considered for cancer screening, in particular if they have anti-Scl70 and anti-RNAP-III antibodies.https://www.frontiersin.org/article/10.3389/fmed.2020.00165/fullneoplasmimmune systemautoimmune diseasesimmunologic testsprognosis
collection DOAJ
language English
format Article
sources DOAJ
author Amandine Gauderon
Pascale Roux-Lombard
Pascale Roux-Lombard
David Spoerl
David Spoerl
spellingShingle Amandine Gauderon
Pascale Roux-Lombard
Pascale Roux-Lombard
David Spoerl
David Spoerl
Antinuclear Antibodies With a Homogeneous and Speckled Immunofluorescence Pattern Are Associated With Lack of Cancer While Those With a Nucleolar Pattern With the Presence of Cancer
Frontiers in Medicine
neoplasm
immune system
autoimmune diseases
immunologic tests
prognosis
author_facet Amandine Gauderon
Pascale Roux-Lombard
Pascale Roux-Lombard
David Spoerl
David Spoerl
author_sort Amandine Gauderon
title Antinuclear Antibodies With a Homogeneous and Speckled Immunofluorescence Pattern Are Associated With Lack of Cancer While Those With a Nucleolar Pattern With the Presence of Cancer
title_short Antinuclear Antibodies With a Homogeneous and Speckled Immunofluorescence Pattern Are Associated With Lack of Cancer While Those With a Nucleolar Pattern With the Presence of Cancer
title_full Antinuclear Antibodies With a Homogeneous and Speckled Immunofluorescence Pattern Are Associated With Lack of Cancer While Those With a Nucleolar Pattern With the Presence of Cancer
title_fullStr Antinuclear Antibodies With a Homogeneous and Speckled Immunofluorescence Pattern Are Associated With Lack of Cancer While Those With a Nucleolar Pattern With the Presence of Cancer
title_full_unstemmed Antinuclear Antibodies With a Homogeneous and Speckled Immunofluorescence Pattern Are Associated With Lack of Cancer While Those With a Nucleolar Pattern With the Presence of Cancer
title_sort antinuclear antibodies with a homogeneous and speckled immunofluorescence pattern are associated with lack of cancer while those with a nucleolar pattern with the presence of cancer
publisher Frontiers Media S.A.
series Frontiers in Medicine
issn 2296-858X
publishDate 2020-04-01
description Background: Different antinuclear antibody (ANA) patterns have been associated with the presence of cancer, while other are typically seen in autoimmune diseases. This study aims to investigate the association between ANA and cancer, focusing on patients with ANA with a nucleolar indirect immunofluorescence (IIF) pattern.Materials and Methods: ANA patterns and positivity of antibodies against nuclear antigens (NA), in particular those responsible for a nucleolar ANA pattern and/or associated with systemic sclerosis (CENP-A/B, fibrillarin, Ku, NOR-90, PM/Scl-100, PM/Scl-75, RNAP-III, Scl-70, Ro52/TRIM21, and Th/To) were analyzed and correlated to an internal database of patients with cancer.Results: The study included 15,728 patients who had an ANA analysis, 386 patients who had immunodot analysis for antibody/ies against/to specific NA and 15,701 patients diagnosed with cancer. The presence of ANA with a nucleolar pattern showed an increased relative risk (RR 1.5, 95%CI 1.03-2.3) for an associated cancer. Anti-Scl70 and anti-RNAP-III were associated with cancer in 15 and 14%, respectively. The presence of ANA with a homogeneous & speckled (HS) pattern was significantly associated with the absence of cancer (p < 0.01). Patients with a HS pattern were found to have a lower relative risk (RR 0.7, 95%CI 0.5-0.9) of having cancer compared to those with other patterns.Conclusions: Larger studies are needed to investigate which particular antibody/ies against/to specific NA is responsible for the association between nucleolar ANA and cancer, but anti-Scl70 and anti-RNAP-III, which is frequently associated with the presence of anti-RNAP-I, are good candidates to explain this association. Patients with a nucleolar pattern might be considered for cancer screening, in particular if they have anti-Scl70 and anti-RNAP-III antibodies.
topic neoplasm
immune system
autoimmune diseases
immunologic tests
prognosis
url https://www.frontiersin.org/article/10.3389/fmed.2020.00165/full
work_keys_str_mv AT amandinegauderon antinuclearantibodieswithahomogeneousandspeckledimmunofluorescencepatternareassociatedwithlackofcancerwhilethosewithanucleolarpatternwiththepresenceofcancer
AT pascalerouxlombard antinuclearantibodieswithahomogeneousandspeckledimmunofluorescencepatternareassociatedwithlackofcancerwhilethosewithanucleolarpatternwiththepresenceofcancer
AT pascalerouxlombard antinuclearantibodieswithahomogeneousandspeckledimmunofluorescencepatternareassociatedwithlackofcancerwhilethosewithanucleolarpatternwiththepresenceofcancer
AT davidspoerl antinuclearantibodieswithahomogeneousandspeckledimmunofluorescencepatternareassociatedwithlackofcancerwhilethosewithanucleolarpatternwiththepresenceofcancer
AT davidspoerl antinuclearantibodieswithahomogeneousandspeckledimmunofluorescencepatternareassociatedwithlackofcancerwhilethosewithanucleolarpatternwiththepresenceofcancer
_version_ 1724654452523139072