Continuous Inflammatory Stimulation Leads via Metabolic Plasticity to a Prometastatic Phenotype in Triple-Negative Breast Cancer Cells

Continuous Inflammatory Stimulation Leads via Metabolic Plasticity to a Prometastatic Phenotype in Triple-Negative Breast Cancer Cells

Chronic inflammation promotes cancer progression by affecting the tumor cells and their microenvironment. Here, we demonstrate that a continuous stimulation (~6 weeks) of triple-negative breast tumor cells (TNBC) by the proinflammatory cytokines tumor necrosis factor α (TNFα) + interleukin 1β (IL-1β...

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Bibliographic Details
Main Authors: Dina Morein, Linor Rubinstein-Achiasaf, Hadar Brayer, Orly Dorot, Edward Pichinuk, Hagar Ben-Yaakov, Tsipi Meshel, Metsada Pasmanik-Chor, Adit Ben-Baruch
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cells
Subjects:
glycolysis
inflammation
interleukin 1β
leukocyte migration
metabolism
oxidative phosphorylation
Online Access:https://www.mdpi.com/2073-4409/10/6/1356

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