Human hepatocyte growth factor promotes functional recovery in primates after spinal cord injury.

Human hepatocyte growth factor promotes functional recovery in primates after spinal cord injury.

Many therapeutic interventions for spinal cord injury (SCI) using neurotrophic factors have focused on reducing the area damaged by secondary, post-injury degeneration, to promote functional recovery. Hepatocyte growth factor (HGF), which is a potent mitogen for mature hepatocytes and a mediator of...

Full description

Bibliographic Details
Main Authors:	Kazuya Kitamura, Kanehiro Fujiyoshi, Jun-Ichi Yamane, Fumika Toyota, Keigo Hikishima, Tatsuji Nomura, Hiroshi Funakoshi, Toshikazu Nakamura, Masashi Aoki, Yoshiaki Toyama, Hideyuki Okano, Masaya Nakamura
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2011-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3226561?pdf=render

Similar Items

MRI characterization of paranodal junction failure and related spinal cord changes in mice.
by: Morito Takano, et al.
Published: (2012-01-01)

Application of Hepatocyte Growth Factor for Acute Spinal Cord Injury: The Road from Basic Studies to Human Treatment
by: Kazuya Kitamura, et al.
Published: (2019-02-01)

Pre-evaluated safe human iPSC-derived neural stem cells promote functional recovery after spinal cord injury in common marmoset without tumorigenicity.
by: Yoshiomi Kobayashi, et al.
Published: (2012-01-01)

Transplantation of Neural Stem/Progenitor Cells at Different Locations in Mice with Spinal Cord Injury
by: Hiroki Iwai, et al.
Published: (2014-11-01)

Noninvasive technique to evaluate the muscle fiber characteristics using q-space imaging.
by: Junichi Hata, et al.
Published: (2019-01-01)

Roles of ES cell-derived gliogenic neural stem/progenitor cells in functional recovery after spinal cord injury.
by: Gentaro Kumagai, et al.
Published: (2009-11-01)

Mimicking the neurotrophic factor profile of embryonic spinal cord controls the differentiation potential of spinal progenitors into neuronal cells.
by: Masaya Nakamura, et al.
Published: (2011-01-01)

Time-dependent changes in the microenvironment of injured spinal cord affects the therapeutic potential of neural stem cell transplantation for spinal cord injury
by: Nishimura Soraya, et al.
Published: (2013-01-01)

Improvement of Sepsis by Hepatocyte Growth Factor, an Anti-Inflammatory Regulator: Emerging Insights and Therapeutic Potential
by: Shinya Mizuno, et al.
Published: (2012-01-01)

Novel Concept of Motor Functional Analysis for Spinal Cord Injury in Adult Mice
by: Munehisa Shinozaki, et al.
Published: (2011-01-01)

The prospects of regenerative medicine combined with rehabilitative approaches for chronic spinal cord injury animal models
by: Syoichi Tashiro, et al.
Published: (2017-01-01)

Regenerative therapy for spinal cord injury using iPSC technology
by: Narihito Nagoshi, et al.
Published: (2020-10-01)

In vivo microscopic voxel-based morphometry with a brain template to characterize strain-specific structures in the mouse brain
by: Keigo Hikishima, et al.
Published: (2017-03-01)

Transplantation of human neural stem/progenitor cells overexpressing galectin-1 improves functional recovery from focal brain ischemia in the mongolian gerbil
by: Yamane Junichi, et al.
Published: (2011-09-01)

Efficient derivation of multipotent neural stem/progenitor cells from non-human primate embryonic stem cells.
by: Hiroko Shimada, et al.
Published: (2012-01-01)

Comparative Study of Methods for Administering Neural Stem/Progenitor Cells to Treat Spinal Cord Injury in Mice
by: Yuichiro Takahashi, et al.
Published: (2011-06-01)

Implication of Tryptophan 2,3-Dioxygenase and its Novel Variants in the Hippocampus and Cerebellum during the Developing and Adult Brain
by: Masaaki Kanai, et al.
Published: (2010-01-01)

Implication of Tryptophan 2,3-Dioxygenase and its Novel Variants in the Hippocampus and Cerebellum During the Developing and Adult Brain
by: Masaaki Kanai, et al.
Published: (2010-07-01)

Modulation of Tryptophan Metabolism, Promotion of Neurogenesis and Alteration of Anxiety-Related Behavior in Tryptophan 2,3-Dioxygenase-Deficient Mice
by: Hiroshi Funakoshi, et al.
Published: (2011-01-01)

Modulation of Tryptophan Metabolism, Promotion of Neurogenesis and Alteration of Anxiety-Related Behavior in Tryptophan 2,3-Dioxygenase-Deficient Mice
by: Hiroshi Funakoshi, et al.
Published: (2011-04-01)

Cell therapy for spinal cord injury using induced pluripotent stem cells
by: Narihito Nagoshi, et al.
Published: (2019-12-01)

Control of the Survival and Growth of Human Glioblastoma Grafted into the Spinal Cord of Mice by Taking Advantage of Immunorejection
by: Go Itakura, et al.
Published: (2015-07-01)

Controlling immune rejection is a fail-safe system against potential tumorigenicity after human iPSC-derived neural stem cell transplantation.
by: Go Itakura, et al.
Published: (2015-01-01)

Différenciation des cellules souches embryonnaires humaines vers l'hépatocyte
by: Funakoshi, Natalie
Published: (2011)

Schwann-spheres derived from injured peripheral nerves in adult mice--their in vitro characterization and therapeutic potential.
by: Takehiko Takagi, et al.
Published: (2011-01-01)

Genetic Modification of Hepatocytes towards Hepatocyte Transplantation and Liver Tissue Engineering
by: Hiroyuki Kuge, et al.
Published: (2006-01-01)

Distinct Expression Pattern of a Deafness Gene, KIAA1199, in a Primate Cochlea
by: Makoto Hosoya, et al.
Published: (2016-01-01)

Dynamic Spatiotemporal Expression Changes in Connexins of the Developing Primate’s Cochlea
by: Makoto Hosoya, et al.
Published: (2021-07-01)

Intraventricular administration of hepatocyte growth factor treats mouse communicating hydrocephalus induced by transforming growth factor β1
by: Tsuyoshi Tada, et al.
Published: (2006-03-01)

Expression of tryptophan 2,3-dioxygenase in mature granule cells of the adult mouse dentate gyrus
by: Ohira, Koji, et al.
Published: (2010-09-01)

Hepatocyte growth factor stimulates neutrophil degranulation but not respiratory burst
by: I. C. Kowanko, et al.
Published: (1993-01-01)

Meridional distribution and seasonal variation of stable oxygen isotope ratio of precipitation in the Southern Ocean
by: Kayo Nakamura, et al.
Published: (2010-07-01)

The dual origin of the peripheral olfactory system: placode and neural crest
by: Katoh Hiroyuki, et al.
Published: (2011-09-01)

Multidimensional MRI-CT atlas of the naked mole-rat brain
by: Fumiko eSeki, et al.
Published: (2013-12-01)

Tryptophan-Restriction Diets Help to Maintain L-Tryptophan Homeostasis in Tryptophan 2,3-Dioxygenase Knockout Mice
by: Akihiro Maeta, et al.
Published: (2013-07-01)

Tryptophan-Restriction Diets Help to Maintain L-Tryptophan Homeostasis in Tryptophan 2,3-Dioxygenase Knockout Mice
by: Akihiro Maeta, et al.
Published: (2013-01-01)

Measurement of Neutrino Oscillation with a High Intensity Neutrino Beam
by: Nakamura, Keigo
Published: (2019)

Optogenetic activation of CA1 pyramidal neurons at the dorsal and ventral hippocampus evokes distinct brain-wide responses revealed by mouse fMRI.
by: Norio Takata, et al.
Published: (2015-01-01)

Clinical Efficacies of the Minimal Retroperitoneal Approach for Infectious Spondylodiscitis: A Clinical Case Series
by: Tsunehiko Konomi, et al.
Published: (2021-05-01)

Novel in vivo imaging analysis of an inner ear drug delivery system in mice: comparison of inner ear drug concentrations over time after transtympanic and systemic injections.
by: Sho Kanzaki, et al.
Published: (2012-01-01)