In Vitro and In Vivo Evaluation of a Folate-Targeted Copolymeric Submicrohydrogel Based on N-Isopropylacrylamide as 5-Fluorouracil Delivery System

In Vitro and In Vivo Evaluation of a Folate-Targeted Copolymeric Submicrohydrogel Based on N-Isopropylacrylamide as 5-Fluorouracil Delivery System

Folate-targeted poly[(p-nitrophenyl acrylate)-co-(N-isopropylacrylamide)] nanohydrogel (F-SubMG) was loaded with 5-fluorouracil (5-FU) to obtain low (16.3 ± 1.9 μg 5-FU/mg F-SubMG) and high (46.8 ± 3.8 μg 5-FU/mg F-SubMG) load 5-FU-loaded F-SubMGs. The complete in vitro drug release took place in 8...

Full description

Bibliographic Details
Main Authors: José M. Teijón, Ana Fernández, Issa Katime, Rosa Olmo, César Teijón, Marta Benito, M. Dolores Blanco, Sandra Guerrero
Format: Article
Language:English
Published: MDPI AG 2011-07-01
Series:Polymers
Subjects:
drug delivery
folate-conjugate nanogel
5-fluorouracil
culture cells
pharmacokinetic
Online Access:http://www.mdpi.com/2073-4360/3/3/1107/

Similar Items

Similar Items