Successful allogeneic bone marrow transplantation using immunosuppressive conditioning regimen for a patient with red blood cell transfusion-dependent pyruvate kinase deficiency anemia

Successful allogeneic bone marrow transplantation using immunosuppressive conditioning regimen for a patient with red blood cell transfusion-dependent pyruvate kinase deficiency anemia

Pyruvate kinase deficiency (PKD) is the rare glycolytic enzyme defect causing hemolytic anemia. Treatments are mainly red cell transfusion and/or splenectomy, leading to iron overload. Allogeneic bone marrow transplantation (BMT) is alternatively curative treatment for severe PKD. The intensity of...

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Bibliographic Details
Main Authors: Maiko Shimomura, Takehiko Doi, Shiho Nishimura, Yusuke Imanaka, Shuhei Karakawa, Satoshi Okada, Hiroshi Kawaguchi, Masao Kobayashi
Format: Article
Language:English
Published: PAGEPress Publications 2020-05-01
Series:Hematology Reports
Subjects:
Pyruvate kinase deficiency
allogeneic hematopoietic cell transplantation
immunosuppressive conditioning regimen
Online Access:https://www.pagepress.org/journals/index.php/hr/article/view/8305

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