The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα

Peroxisome Proliferator Activated Receptor alpha (PPARα) drives fatty acid catabolism. Here, the authors show that in liver of autophagy deficient class 3 phosphoinositide 3-kinase mutant mice PPARα transcriptional repressors fail to degrade in lysosomes and accumulate leading to PPARα inhibition an...

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Main Authors:	Anton Iershov, Ivan Nemazanyy, Chantal Alkhoury, Muriel Girard, Esther Barth, Nicolas Cagnard, Alexandra Montagner, Dominique Chretien, Elena I. Rugarli, Herve Guillou, Mario Pende, Ganna Panasyuk
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-09598-9

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spelling	doaj-942549d8fc9a4e9396af183cc1bf56452021-05-11T12:40:24ZengNature Publishing GroupNature Communications2041-17232019-04-0110111810.1038/s41467-019-09598-9The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARαAnton Iershov0Ivan Nemazanyy1Chantal Alkhoury2Muriel Girard3Esther Barth4Nicolas Cagnard5Alexandra Montagner6Dominique Chretien7Elena I. Rugarli8Herve Guillou9Mario Pende10Ganna Panasyuk11Institut Necker-Enfants Malades (INEM)Institut Necker-Enfants Malades (INEM)Institut Necker-Enfants Malades (INEM)Institut Necker-Enfants Malades (INEM)Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of ColognePlateforme Bio-informatique, Université Paris Descartes, Structure Fédérative de Recherche Necker, INSERM US24/CNRS UMS 3633INSERM U1048, Université Paul SabatierINSERM UMR1141, Hôpital Robert DebréInstitute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of CologneToxalim, Université de Toulouse, INRA, ENVT, INP-Purpan, UPSInstitut Necker-Enfants Malades (INEM)Institut Necker-Enfants Malades (INEM)Peroxisome Proliferator Activated Receptor alpha (PPARα) drives fatty acid catabolism. Here, the authors show that in liver of autophagy deficient class 3 phosphoinositide 3-kinase mutant mice PPARα transcriptional repressors fail to degrade in lysosomes and accumulate leading to PPARα inhibition and blunted transcriptional responses during fasting.https://doi.org/10.1038/s41467-019-09598-9
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Anton Iershov Ivan Nemazanyy Chantal Alkhoury Muriel Girard Esther Barth Nicolas Cagnard Alexandra Montagner Dominique Chretien Elena I. Rugarli Herve Guillou Mario Pende Ganna Panasyuk
spellingShingle	Anton Iershov Ivan Nemazanyy Chantal Alkhoury Muriel Girard Esther Barth Nicolas Cagnard Alexandra Montagner Dominique Chretien Elena I. Rugarli Herve Guillou Mario Pende Ganna Panasyuk The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα Nature Communications
author_facet	Anton Iershov Ivan Nemazanyy Chantal Alkhoury Muriel Girard Esther Barth Nicolas Cagnard Alexandra Montagner Dominique Chretien Elena I. Rugarli Herve Guillou Mario Pende Ganna Panasyuk
author_sort	Anton Iershov
title	The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα
title_short	The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα
title_full	The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα
title_fullStr	The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα
title_full_unstemmed	The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα
title_sort	class 3 pi3k coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor pparα
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-04-01
description	Peroxisome Proliferator Activated Receptor alpha (PPARα) drives fatty acid catabolism. Here, the authors show that in liver of autophagy deficient class 3 phosphoinositide 3-kinase mutant mice PPARα transcriptional repressors fail to degrade in lysosomes and accumulate leading to PPARα inhibition and blunted transcriptional responses during fasting.
url	https://doi.org/10.1038/s41467-019-09598-9
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The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα

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