PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth

Proline metabolism is crucial to tumor proliferation. Here, the authors show PINCH-1 deficiency inhibited proline synthesis by promoting mitochondrial fragmentation via DRP1, downregulating PYCR1 expression and reducing cell proliferation in vitro and in vivo.

Bibliographic Details
Main Authors:	Ling Guo, Chunhong Cui, Jiaxin Wang, Jifan Yuan, Qingyang Yang, Ping Zhang, Wen Su, Ruolu Bao, Jingchao Ran, Chuanyue Wu
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-18753-6

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spelling	doaj-9424d0611639496d99200fb2dc0011802021-10-03T11:52:37ZengNature Publishing GroupNature Communications2041-17232020-10-0111112010.1038/s41467-020-18753-6PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growthLing Guo0Chunhong Cui1Jiaxin Wang2Jifan Yuan3Qingyang Yang4Ping Zhang5Wen Su6Ruolu Bao7Jingchao Ran8Chuanyue Wu9Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Academy for Advanced Interdisciplinary Studies and Department of Biology, Southern University of Science and TechnologyGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Academy for Advanced Interdisciplinary Studies and Department of Biology, Southern University of Science and TechnologyGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Academy for Advanced Interdisciplinary Studies and Department of Biology, Southern University of Science and TechnologyGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Academy for Advanced Interdisciplinary Studies and Department of Biology, Southern University of Science and TechnologyGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Academy for Advanced Interdisciplinary Studies and Department of Biology, Southern University of Science and TechnologyGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Academy for Advanced Interdisciplinary Studies and Department of Biology, Southern University of Science and TechnologyDepartment of Pathology, Shenzhen University Health Science CenterDepartment of Pathology, Shenzhen University Health Science CenterGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Academy for Advanced Interdisciplinary Studies and Department of Biology, Southern University of Science and TechnologyDepartment of Pathology, University of Pittsburgh School of MedicineProline metabolism is crucial to tumor proliferation. Here, the authors show PINCH-1 deficiency inhibited proline synthesis by promoting mitochondrial fragmentation via DRP1, downregulating PYCR1 expression and reducing cell proliferation in vitro and in vivo.https://doi.org/10.1038/s41467-020-18753-6
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ling Guo Chunhong Cui Jiaxin Wang Jifan Yuan Qingyang Yang Ping Zhang Wen Su Ruolu Bao Jingchao Ran Chuanyue Wu
spellingShingle	Ling Guo Chunhong Cui Jiaxin Wang Jifan Yuan Qingyang Yang Ping Zhang Wen Su Ruolu Bao Jingchao Ran Chuanyue Wu PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth Nature Communications
author_facet	Ling Guo Chunhong Cui Jiaxin Wang Jifan Yuan Qingyang Yang Ping Zhang Wen Su Ruolu Bao Jingchao Ran Chuanyue Wu
author_sort	Ling Guo
title	PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth
title_short	PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth
title_full	PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth
title_fullStr	PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth
title_full_unstemmed	PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth
title_sort	pinch-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-10-01
description	Proline metabolism is crucial to tumor proliferation. Here, the authors show PINCH-1 deficiency inhibited proline synthesis by promoting mitochondrial fragmentation via DRP1, downregulating PYCR1 expression and reducing cell proliferation in vitro and in vivo.
url	https://doi.org/10.1038/s41467-020-18753-6
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PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth

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