Calcium ionophore (A-23187) induced peritoneal eicosanoid biosynthesis: a rapid method to evaluate inhibitors of arachidonic acid metabolism in vivo

Calcium ionophore (A-23187) induced peritoneal eicosanoid biosynthesis: a rapid method to evaluate inhibitors of arachidonic acid metabolism in vivo

The present investigation characterizes calcium ionophore (A-23187) induced peritoneal eicosanoid biosynthesis in the rat. Intraperitoneal injection of A-23187 (20 μg/rat) stimulated marked biosynthesis of 6-keto-PGF1α (6-KPA), TxB2, LTC4 and LTB4, with no detectable changes on levels of PGE2. Level...

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Bibliographic Details
Main Authors:	T. S. Rao, J. L. Currie, A. F. Shaffer, P. C. Isakson
Format:	Article
Language:	English
Published:	Hindawi Limited 1993-01-01
Series:	Mediators of Inflammation
Online Access:	http://dx.doi.org/10.1155/S0962935193000493

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