Effects of oral nutrition support on nutritional status, immune function and radiation damage in patients with nasopharyngeal carcinoma radiotherapy
Objective: To study the effects of oral nutrition support on nutritional status, immune function and radiation damage in patients with nasopharyngeal carcinoma radiotherapy. Methods: Patients with nasopharyngeal carcinoma who received radiotherapy in West China Hospital between and November Janua...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Editorial Board of Journal of Hainan Medical University
2018-09-01
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| Series: | Journal of Hainan Medical University |
| Subjects: | |
| Online Access: | http://www.hnykdxxb.com/PDF/201809/15.pdf |
| Summary: | Objective: To study the effects of oral nutrition support on nutritional status, immune function
and radiation damage in patients with nasopharyngeal carcinoma radiotherapy. Methods:
Patients with nasopharyngeal carcinoma who received radiotherapy in West China Hospital
between and November January 2017 were selected and randomly divided into the nutrition
support group who received oral nutrition support and the normal control group who received
routine intervention. The levels of nutrition indicators and radiation damage indicators in
serum as well as the contents of immune cells in peripheral blood were determined before
radiotherapy and 1 week after end of radiotherapy. Results: Compared with those before
radiotherapy, serum ALB, PA, TWEAK, Leptin and Ghrelin levels as well as peripheral blood
CD3+CD4+, CD3+CD8+, CD3-CD19+ and CD3-CD56+ immune cell contents of nutrition
support group didn’t change significantly whereas serum TGF-β1, IL-6, IL-17 and MMP9
levels increased significantly 1 week after end of radiotherapy; serum ALB and PA levels as
well as peripheral blood CD3+CD4+, CD3+CD8+, CD3-CD19+ and CD3-CD56+ immune
cell contents of normal control group decreased significantly whereas TWEAK, Leptin,
Ghrelin, TGF-β1, IL-6, IL-17 and MMP9 levels increased significantly 1 week after end of
radiotherapy. Conclusion: Oral nutrition support can avoid the damage of nutritional status and
immune function and reduce the radiation damage in patients with nasopharyngeal carcinoma
radiotherapy. |
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| ISSN: | 1007-1237 1007-1237 |