The Clinical Effects of Febuxostat Alone or Combined with Arthroscopic Surgery for Gout: A Single-Center Retrospective Study

• Main Authors: Gong Z, Xia L, Xu R, Luo M, Deng H, Kang Z, Liu L, Liu Y, Zhang F, Shi J
• Format: Article
• Language: English
• Published: Dove Medical Press 2021-09-01
• Series: Journal of Inflammation Research
• Subjects: arthroscopy; febuxostat; crystal deposition; tophi; gout
• Online Access: https://www.dovepress.com/the-clinical-effects-of-febuxostat-alone-or-combined-with-arthroscopic-peer-reviewed-fulltext-article-JIR

Zhen Gong,1 Li Xia,1 Rune Xu,1 Min Luo,1 Hongxiang Deng,1 Zhiping Kang,1 Leping Liu,1 Yaqing Liu,1 Fangjie Zhang,2 Jian Shi1 1Department of Rheumatology, Yiyang Central Hospital, Yiyang, Hunan, People’s Republic of China; 2Department of Emergency Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of ChinaCorrespondence: Fangjie ZhangDepartment of Emergency Medicine, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, Hunan, 410008, People’s Republic of ChinaTel [phone]Email [e-mail] ShiDepartment of Rheumatology, Yiyang Central Hospital, No. 118 Kangfu North Road, Yiyang, Hunan, 413000, People’s Republic of ChinaTel [phone]Email [e-mail]: The purpose of the study was to retrospectively analyze the effects of febuxostat combined with arthroscopic debridement of monosodium urate crystal deposition and febuxostat treatment alone on uric acid levels and acute flares in gout patients.Patients and Methods: We retrospectively analyzed gout patients who were treated from February 2016 to December 2020. Patients were divided into a control group (febuxostat treatment alone) or a combined group (febuxostat combined with arthroscopic surgery). We recorded and analyzed clinical data including age, sex, body mass index, comorbidities, lesion affected joints, acute flare times, medications history, febuxostat side effects, arthroscopic complications, and serum creatinine and uric acid levels changes.Results: There were 80 patients in the control group and 93 patients in the combined group. At the beginning of treatment, the combined group had significantly higher disease severity (higher serum uric acid levels and more acute gout flare times). Arthroscopy was performed in 61 knees and 38 ankles, and 86 joints showed crystals deposition. Compared with baseline, follow-up results showed that serum creatinine significantly decreased in the combined group, and serum uric acid and acute gout flare times significantly decreased in both groups (all p < 0.05). In the comparison between the two groups at the follow-up endpoint, acute gout flare times did not differ significantly (p > 0.05), however, serum creatinine and uric acid levels were lower in the combined group compared with those in the control group (ps < 0.05).Conclusion: Febuxostat combined with arthroscopic debridement of monosodium urate crystal deposition or tophi had a superior effect on lowering uric acid levels and acute flare times in gout patients than did febuxostat alone.Keywords: arthroscopy, febuxostat, crystal deposition, tophi, gout