Hypoxia theranostics of a human prostate cancer xenograft and the resulting effects on the tumor microenvironment

Hypoxia theranostics of a human prostate cancer xenograft and the resulting effects on the tumor microenvironment

Hypoxia is frequently observed in human prostate cancer, and is associated with chemoresistance, radioresistance, metastasis, and castrate-resistance. Our purpose in these studies was to perform hypoxia theranostics by combining in vivo hypoxia imaging and hypoxic cancer cell targeting in a human pr...

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Bibliographic Details
Main Authors: Balaji Krishnamachary, Yelena Mironchik, Desmond Jacob, Eibhlin Goggins, Samata Kakkad, Francis Ofori, Louis Dore-Savard, Santosh Kumar Bharti, Flonne Wildes, Marie-France Penet, Margaret E Black, Zaver M Bhujwalla
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Hypoxia
Prodrug enzyme
Imaging
Prostate cancer
Cancer-associated fibroblasts
Collagen 1 fibers
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558620301561

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http://www.sciencedirect.com/science/article/pii/S1476558620301561

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