Deciphering the Role of Filamin B Calponin-Homology Domain in Causing the Larsen Syndrome, Boomerang Dysplasia, and Atelosteogenesis Type I Spectrum Disorders via a Computational Approach

Deciphering the Role of Filamin B Calponin-Homology Domain in Causing the Larsen Syndrome, Boomerang Dysplasia, and Atelosteogenesis Type I Spectrum Disorders via a Computational Approach

Filamins (FLN) are a family of actin-binding proteins involved in regulating the cytoskeleton and signaling phenomenon by developing a network with F-actin and FLN-binding partners. The FLN family comprises three conserved isoforms in mammals: FLNA, FLNB, and FLNC. FLNB is a multidomain monomer prot...

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Bibliographic Details
Main Authors: Udhaya Kumar S., Srivarshini Sankar, Salma Younes, Thirumal Kumar D., Muneera Naseer Ahmad, Sarah Samer Okashah, Balu Kamaraj, Abeer Mohammed Al-Subaie, George Priya Doss C., Hatem Zayed
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Molecules
Subjects:
FLNB
CH2 domain
Larsen syndrome
boomerang dysplasia
atelosteogenesis type I
molecular dynamics simulation (MDS)
Online Access:https://www.mdpi.com/1420-3049/25/23/5543

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https://www.mdpi.com/1420-3049/25/23/5543

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