Niacin increases HDL biogenesis by enhancing DR4-dependent transcription of ABCA1 and lipidation of apolipoprotein A-I in HepG2 cells

Niacin increases HDL biogenesis by enhancing DR4-dependent transcription of ABCA1 and lipidation of apolipoprotein A-I in HepG2 cells

The lipidation of apoA-I in liver greatly influences HDL biogenesis and plasma HDL levels by stabilizing the secreted apoA-I. Niacin is the most effective lipid-regulating agent clinically available to raise HDL. This study was undertaken to identify regulatory mechanisms of niacin action in hepatic...

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Bibliographic Details
Main Authors: Lin-Hua Zhang, Vaijinath S. Kamanna, Shobha H. Ganji, Xi-Ming Xiong, Moti L. Kashyap
Format: Article
Language:English
Published: Elsevier 2012-05-01
Series:Journal of Lipid Research
Subjects:
high density lipoproteins
apolipoprotein A-I
ATP binding cassette transporterA1
direct repeat 4
HDL biogenesis
human hepatoblstoma cell line
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520392245

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http://www.sciencedirect.com/science/article/pii/S0022227520392245

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