Chemopreventive Effect of Aerosolized Polyphenon E on Lung Tumorigenesis in A/J Mice
Effective chemoprevention of lung cancer in high-risk patients through the administration of pharmacologic or nutritional agents is urgently needed. Aerosol inhalation can deliver chemopreventive agents directly to the respiratory tract to inhibit the tumorigenic process. In this study, polyphenon...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2007-05-01
|
| Series: | Neoplasia: An International Journal for Oncology Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S147655860780090X |
| id |
doaj-93e05aef7e234136aa81cc6f2b8bd240 |
|---|---|
| record_format |
Article |
| spelling |
doaj-93e05aef7e234136aa81cc6f2b8bd2402020-11-24T22:54:15ZengElsevierNeoplasia: An International Journal for Oncology Research1476-55861522-80022007-05-019540140510.1593/neo.07160Chemopreventive Effect of Aerosolized Polyphenon E on Lung Tumorigenesis in A/J MiceYing Yan0Julie Cook1Jay McQuillan2Guifang Zhang3Cory J. Hitzman4Yian Wang5Timothy S. Wiedmann6Ming You7Department of Surgery, The Alvin J. Siteman Cancer Center, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St. Louis, MO 63110, USADepartment of Surgery, The Alvin J. Siteman Cancer Center, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St. Louis, MO 63110, USADepartment of Surgery, The Alvin J. Siteman Cancer Center, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St. Louis, MO 63110, USADepartment of Pharmaceutics, University of Minnesota, Minneapolis, MN 55455, USADepartment of Pharmaceutics, University of Minnesota, Minneapolis, MN 55455, USADepartment of Surgery, The Alvin J. Siteman Cancer Center, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St. Louis, MO 63110, USADepartment of Pharmaceutics, University of Minnesota, Minneapolis, MN 55455, USADepartment of Surgery, The Alvin J. Siteman Cancer Center, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St. Louis, MO 63110, USA Effective chemoprevention of lung cancer in high-risk patients through the administration of pharmacologic or nutritional agents is urgently needed. Aerosol inhalation can deliver chemopreventive agents directly to the respiratory tract to inhibit the tumorigenic process. In this study, polyphenon E (PolyE) and (-)epigallocatechin-3-gal late (EGCG) were administered by aerosol delivery to A/J mice beginning 2 weeks after carcinogen treatment and continuing daily by inhalation throughout the remainder of the study (20 weeks). PolyE decreased tumor load by ∼ 59%. However, EGCG, both at the same dose and at a higher dose, failed to inhibit lung carcinogenesis. These results indicate that aerosol delivery of PolyE, but not EGCG, may be a useful chemopreventive protocol in subjects at high risk for lung cancer. http://www.sciencedirect.com/science/article/pii/S147655860780090XAerosolpolyphenon Emouselung tumorigenesischemoprevention |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Ying Yan Julie Cook Jay McQuillan Guifang Zhang Cory J. Hitzman Yian Wang Timothy S. Wiedmann Ming You |
| spellingShingle |
Ying Yan Julie Cook Jay McQuillan Guifang Zhang Cory J. Hitzman Yian Wang Timothy S. Wiedmann Ming You Chemopreventive Effect of Aerosolized Polyphenon E on Lung Tumorigenesis in A/J Mice Neoplasia: An International Journal for Oncology Research Aerosol polyphenon E mouse lung tumorigenesis chemoprevention |
| author_facet |
Ying Yan Julie Cook Jay McQuillan Guifang Zhang Cory J. Hitzman Yian Wang Timothy S. Wiedmann Ming You |
| author_sort |
Ying Yan |
| title |
Chemopreventive Effect of Aerosolized Polyphenon E on Lung Tumorigenesis in A/J Mice |
| title_short |
Chemopreventive Effect of Aerosolized Polyphenon E on Lung Tumorigenesis in A/J Mice |
| title_full |
Chemopreventive Effect of Aerosolized Polyphenon E on Lung Tumorigenesis in A/J Mice |
| title_fullStr |
Chemopreventive Effect of Aerosolized Polyphenon E on Lung Tumorigenesis in A/J Mice |
| title_full_unstemmed |
Chemopreventive Effect of Aerosolized Polyphenon E on Lung Tumorigenesis in A/J Mice |
| title_sort |
chemopreventive effect of aerosolized polyphenon e on lung tumorigenesis in a/j mice |
| publisher |
Elsevier |
| series |
Neoplasia: An International Journal for Oncology Research |
| issn |
1476-5586 1522-8002 |
| publishDate |
2007-05-01 |
| description |
Effective chemoprevention of lung cancer in high-risk patients through the administration of pharmacologic or nutritional agents is urgently needed. Aerosol inhalation can deliver chemopreventive agents directly to the respiratory tract to inhibit the tumorigenic process. In this study, polyphenon E (PolyE) and (-)epigallocatechin-3-gal late (EGCG) were administered by aerosol delivery to A/J mice beginning 2 weeks after carcinogen treatment and continuing daily by inhalation throughout the remainder of the study (20 weeks). PolyE decreased tumor load by ∼ 59%. However, EGCG, both at the same dose and at a higher dose, failed to inhibit lung carcinogenesis. These results indicate that aerosol delivery of PolyE, but not EGCG, may be a useful chemopreventive protocol in subjects at high risk for lung cancer.
|
| topic |
Aerosol polyphenon E mouse lung tumorigenesis chemoprevention |
| url |
http://www.sciencedirect.com/science/article/pii/S147655860780090X |
| work_keys_str_mv |
AT yingyan chemopreventiveeffectofaerosolizedpolyphenoneonlungtumorigenesisinajmice AT juliecook chemopreventiveeffectofaerosolizedpolyphenoneonlungtumorigenesisinajmice AT jaymcquillan chemopreventiveeffectofaerosolizedpolyphenoneonlungtumorigenesisinajmice AT guifangzhang chemopreventiveeffectofaerosolizedpolyphenoneonlungtumorigenesisinajmice AT coryjhitzman chemopreventiveeffectofaerosolizedpolyphenoneonlungtumorigenesisinajmice AT yianwang chemopreventiveeffectofaerosolizedpolyphenoneonlungtumorigenesisinajmice AT timothyswiedmann chemopreventiveeffectofaerosolizedpolyphenoneonlungtumorigenesisinajmice AT mingyou chemopreventiveeffectofaerosolizedpolyphenoneonlungtumorigenesisinajmice |
| _version_ |
1725661202485346304 |