Porcine IFI16 Negatively Regulates cGAS Signaling Through the Restriction of DNA Binding and Stimulation

Porcine IFI16 Negatively Regulates cGAS Signaling Through the Restriction of DNA Binding and Stimulation

The innate immunity DNA sensors have drawn much attention due to their significant importance against the infections with DNA viruses and intracellular bacteria. Among the multiple DNA sensors, IFI16, and cGAS are the two major ones, subjected to extensive studies. However, these two DNA sensors in...

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Bibliographic Details
Main Authors: Wanglong Zheng, Rongyun Zhou, Shuangjie Li, Shan He, Jia Luo, Meiqin Zhu, Nanhua Chen, Hongjun Chen, François Meurens, Jianzhong Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
innate immunity
DNA sensor
signaling
porcine
mutual relationship
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01669/full

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