Chemical Inhibitors of Dynamin Exert Differential Effects in VEGF Signaling

Chemical Inhibitors of Dynamin Exert Differential Effects in VEGF Signaling

VEGFR2 is the main receptor and mediator of the vasculogenic and angiogenic activity of VEGF. Activated VEGFR2 internalizes through clathrin-mediated endocytosis and macropinocytosis. As dynamin is a key regulator of the clathrin pathway, chemical inhibitors of dynamin are commonly used to assess th...

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Bibliographic Details
Main Authors: Dimitris Basagiannis, Sofia Zografou, Evangeli Goula, Despoina Gkeka, Evangelos Kolettas, Savvas Christoforidis
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cells
Subjects:
cell signaling
endocytosis
vesicular trafficking
dynamin
inhibitors
endothelial cell biology
Online Access:https://www.mdpi.com/2073-4409/10/5/997

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