Evaluating the effect of α-pinene on motor activity, avoidance memory and lipid peroxidation in animal model of Parkinson disease in adult male rats

• Main Authors: S. Goudarzi, M. Rafieirad
• Format: Article
• Language: English
• Published: Iranian Society of Pharmacognosy 2017-04-01
• Series: Research Journal of Pharmacognosy
• Subjects: lipid peroxidation; memory; movement; Parkinson`s disease; α-pinene
• Online Access: http://www.rjpharmacognosy.ir/article_44259_5af5b28e5859412dbc53c78be0276501.pdf

Background and objectives: Parkinson's disease (PD) is a common neuropathologic disorder that is caused by degeneration of dopaminergic neurons of dense part of nigra. Oxidative stress has been found in the pathophysiology of PD. Since α-pinene has strong anti-oxidant effects, the purpose of this research was to study its effects on movement disorders and memory and lipid peroxidation in PD. Methods: Thirty five male rats were divided in 5 groups: control, vehicle, PD (received injection of 6-hydroxydopamine (6-OHDA)) and Parkinson's groups receiving doses of 100 and 200 mg/kg via gavage for two weeks. Generating animal models for Parkinson was done by intracerebral injection of 6-OHDA in the left side of the brain in medial forebrain bundle (MFB). After the injection, the movement balance of the rats was measured by Rotarod. Memory test was done by shuttle box; their brain was extracted to analyze malondialdehyde (MDA) in striatum, hippocampus and blood. Results: The  results showed that Parkinson caused, movement disorder (p