Basement membrane damage by ROS- and JNK-mediated Mmp2 activation drives macrophage recruitment to overgrown tissue

Basement membrane damage by ROS- and JNK-mediated Mmp2 activation drives macrophage recruitment to overgrown tissue

The molecular mechanisms regulating macrophage recruitment to tumors are unclear. Here, the authors use a Drosophila overgrowth model to show how damaged basement membranes recruit macrophages to undead tissue, via an interdependent effect of reactive oxygen species and matrix metalloproteinase 2.

Bibliographic Details
Main Authors: Neha Diwanji, Andreas Bergmann
Format: Article
Language:English
Published: Nature Publishing Group 2020-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17399-8
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spelling doaj-93c2f6af999545048616780f10a3bd532021-07-25T11:39:59ZengNature Publishing GroupNature Communications2041-17232020-07-0111111410.1038/s41467-020-17399-8Basement membrane damage by ROS- and JNK-mediated Mmp2 activation drives macrophage recruitment to overgrown tissueNeha Diwanji0Andreas Bergmann1University of Massachusetts Medical School, Department of Molecular, Cell and Cancer BiologyUniversity of Massachusetts Medical School, Department of Molecular, Cell and Cancer BiologyThe molecular mechanisms regulating macrophage recruitment to tumors are unclear. Here, the authors use a Drosophila overgrowth model to show how damaged basement membranes recruit macrophages to undead tissue, via an interdependent effect of reactive oxygen species and matrix metalloproteinase 2.https://doi.org/10.1038/s41467-020-17399-8
collection DOAJ
language English
format Article
sources DOAJ
author Neha Diwanji
Andreas Bergmann
spellingShingle Neha Diwanji
Andreas Bergmann
Basement membrane damage by ROS- and JNK-mediated Mmp2 activation drives macrophage recruitment to overgrown tissue
Nature Communications
author_facet Neha Diwanji
Andreas Bergmann
author_sort Neha Diwanji
title Basement membrane damage by ROS- and JNK-mediated Mmp2 activation drives macrophage recruitment to overgrown tissue
title_short Basement membrane damage by ROS- and JNK-mediated Mmp2 activation drives macrophage recruitment to overgrown tissue
title_full Basement membrane damage by ROS- and JNK-mediated Mmp2 activation drives macrophage recruitment to overgrown tissue
title_fullStr Basement membrane damage by ROS- and JNK-mediated Mmp2 activation drives macrophage recruitment to overgrown tissue
title_full_unstemmed Basement membrane damage by ROS- and JNK-mediated Mmp2 activation drives macrophage recruitment to overgrown tissue
title_sort basement membrane damage by ros- and jnk-mediated mmp2 activation drives macrophage recruitment to overgrown tissue
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-07-01
description The molecular mechanisms regulating macrophage recruitment to tumors are unclear. Here, the authors use a Drosophila overgrowth model to show how damaged basement membranes recruit macrophages to undead tissue, via an interdependent effect of reactive oxygen species and matrix metalloproteinase 2.
url https://doi.org/10.1038/s41467-020-17399-8
work_keys_str_mv AT nehadiwanji basementmembranedamagebyrosandjnkmediatedmmp2activationdrivesmacrophagerecruitmenttoovergrowntissue
AT andreasbergmann basementmembranedamagebyrosandjnkmediatedmmp2activationdrivesmacrophagerecruitmenttoovergrowntissue
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