Genome and transcriptome profiling of fibrolamellar hepatocellular carcinoma demonstrates p53 and IGF2BP1 dysregulation.

Genome and transcriptome profiling of fibrolamellar hepatocellular carcinoma demonstrates p53 and IGF2BP1 dysregulation.

Fibrolamellar hepatocellular carcinoma (FL-HCC) is a rare variant of HCC that most frequently affects young adults. Because of its rarity and an absence of preclinical models, our understanding of FL-HCC is limited. Our objective was to analyze chromosomal alterations and dysregulated gene expressio...

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Main Authors: Eric C Sorenson, Raya Khanin, Zubin M Bamboat, Michael J Cavnar, Teresa S Kim, Eran Sadot, Shan Zeng, Jonathan B Greer, Adrian M Seifert, Noah A Cohen, Megan H Crawley, Benjamin L Green, David S Klimstra, Ronald P DeMatteo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5423588?pdf=render

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