Role of ceramide in Ca2+-sensing receptor-induced apoptosis

Role of ceramide in Ca2+-sensing receptor-induced apoptosis

Increased extracellular Ca2+ ([Ca2+]o) can damage tissues, but the molecular mechanisms by which this occurs are poorly defined. Using HEK 293 cell lines that stably overexpress the Ca2+-sensing receptor (CaR), a G protein-coupled receptor, we demonstrate that activation of the CaR leads to apoptosi...

Full description

Bibliographic Details
Main Authors: Zhenzhen Wu, Rajnish Tandon, Jenny Ziembicki, Junko Nagano, Kristine M. Hujer, R. Tyler Miller, Chunfa Huang
Format: Article
Language:English
Published: Elsevier 2005-07-01
Series:Journal of Lipid Research
Subjects:
stress-activated protein kinase/c-Jun N-terminal kinase
HEK 293 cell
G protein-coupled receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520329904

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520329904

Similar Items